53064-79-2

Pale Yellow Liquid

Iodomethyl pivalate can be used as reagent used for the addition of pivaloyl group.

The Journal of Organic Chemistry, 48, p. 5280, 1983 DOI: 10.1021/jo00174a024

Iodomethyl pivalate is synthesised using chloromethyl pivalate as a raw material by chemical reaction. The specific synthesis steps are as follows:
Three bottles were added 10.0 g of chloromethyl pivalate, Ethyl acetate 30 mL, 11.6 g of sodium iodide and 3.6 g of calcium chloride, After heating to 78 ° C for 6 h, Cooling to 0 ,Then washed with 5% sodium thiosulfate to colorless, Dried over anhydrous magnesium sulfate, Concentrated under reduced pressure. 16 g of a yellow liquid. Iodomethyl pivalate was obtained. The reaction molar yield was 94% and GC: 98%.