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109-72-8

Supplier Related Products Identification Chemical Properties Safety Data Raw materials And Preparation Products Material Safety Data Sheet(MSDS) Questions And Answer Well-known Reagent Company Product Information

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Identification

Name
n-Butyllithium
CAS
109-72-8
Synonyms
BUTYLLITHIUM
LITHIUM-1-BUTANIDE
LITHIUMBUTYL
N-BULI
N-BUTYLLITHIUM
butyl-lithiu
Lithiumn-butyl
Butyllithium solution
ButyllithiuminhexaneM
BUTYLLITHIUM SOLUTION, ~2.7 M IN HEPTANE
BUTYLLITHIUM SOLUTION, ~2.5 M IN TOLUENE
BUTYLLITHIUM, 2.5M SOLUTION IN HEXANES
BUTYLLITHIUM, 2.0M SOLUTION IN PENTANE
BUTYLLITHIUM, 1.6M SOLUTION IN HEXANES
BUTYLLITHIUM SOLUTION, ~1.6 M IN HEXANE
BUTYLLITHIUM, 2.0M SOLUTION IN CYCLOHEXA NE
BUTYLLITHIUM SOLUTION, ~10 M IN HEXANE
BUTYLLITHIUM, 10.0M SOLUTION IN HEXANES
N-butyl lithium Solution
n-utyllithium
EINECS(EC#)
203-698-7
Molecular Formula
C4H9Li
MDL Number
MFCD00009414
Molecular Weight
64.06
MOL File
109-72-8.mol

Chemical Properties

Appearance
clear yellow-orange to orange-red solution
mp 
-95 °C
bp 
80 °C

density 
0.68 g/mL at 20 °C

Fp 
10 °F

storage temp. 
2-8°C

form 
liquid

color 
yellow

Water Solubility 
vigorous reaction
Sensitive 
Air & Moisture Sensitive
BRN 
1209227
CAS DataBase Reference
109-72-8(CAS DataBase Reference)
Storage Precautions
Air sensitive;Store under nitrogen;Moisture sensitive
NIST Chemistry Reference
Butyl lithium(109-72-8)
EPA Substance Registry System
109-72-8(EPA Substance)

Safety Data

Hazard Codes 
F,C,N
Risk Statements 
R14/15:Reacts violently with water, liberating extremely flammable gases .
R17:Spontaneously flammable in air.
R34:Causes burns.
R48/20:Harmful: danger of serious damage to health by prolonged exposure through inhalation .
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R62:Possible risk of impaired fertility.
R65:Harmful: May cause lung damage if swallowed.
R67:Vapors may cause drowsiness and dizziness.
R63:Possible risk of harm to the unborn child.
R35:Causes severe burns.
R11:Highly Flammable.
R15:Contact with water liberates extremely flammable gases.
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R66:Repeated exposure may cause skin dryness or cracking.
Safety Statements 
S6:Keep under ... (inert gas to be specified by the manufacturer) .
S9:Keep container in a well-ventilated place .
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S62:If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label .
S46:If swallowed, seek medical advice immediately and show this container or label .
S43:In case of fire, use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add-Never use water) .
S60:This material and/or its container must be disposed of as hazardous waste .
S33:Take precautionary measures against static discharges .
S29:Do not empty into drains .
S5:Keep contents under ... (appropriate liquid to be specified by the manufacturer) .
RIDADR 
UN 3399 4.3/PG 1

WGK Germany 
3


3-10
HazardClass 
4.3
PackingGroup 
I
HS Code 
29319090

Raw materials And Preparation Products

Material Safety Data Sheet(MSDS)

Questions And Answer

Chemical Properties
n-Butyllithium is a Colorless or slightly yellow transparent liquid at room temperature, also comes in powder form. Boiling point is 80-90℃(0.013Pa), relative density is 0.68-0.70. Soluble in many organic solvents. Stable in room temperature, lithium hydride removable by heating. Disintegrates in water, soluble in hydrocarbons and ethers, forms complex compounds with ethers, amines, and sulfides, and uses N-hexane as a solvent.
n-Butyllithium
Uses
N-Butyllithium solution is mostly used as a pharmaceutical intermediate to synthesize anionic polymerization initiator. It is also used to produce rubber (such as integral rubber SIBR, which is the most versatile diene rubber to date), fragrance, liquid crystal materials, and other industries. It is a chemical product intermediate, linking agent, alkylating agent, and polymerization catalyst. As a catalyst, N-Butyllithium is widely used as a pharmaceutical intermediate, liquid crystal monomer, and pesticide production catalyst.
N-Butyllithium is also widely used in organic syntheses, especially in growing carbon chains, and it is a staple laboratory product in reactions such as:
1) Metallization reaction: R-H + n-Butyl-Li → R-Li + Butane, in which the produced lithium alkyl can react with many substances.
2) Direct metallization: the aromatic compound that connects the substitute reacts with N-Butyllithium, and lithium metal can be attached to the aromatic compound.
3) Nucleophilic addition and substitution reaction.
4) Halogen-metal replacement.
Identifying Procedures
N-Butyllithium must be calibrated through single titration as follows:
1) Titration solution: 1mol/L SEC butanol/dimethylbenzene solution (butanol and dimethylbenzene must be dried with an activated 5A molecular sieve)
2) Indicator: 2,2’-dipyridine
3) Solvent: dimethylbenzene (must be dried with an activated 5A molecular sieve).
4) Operation method: Under the protection of argon, add magneton, 20ml dimethylbenzene and a small amount of indicator into a 100ml 3-lipped bottle with a tipping plug. Then use a precisely marked 2ml injector to swiftly transfer 2ml N-Butyllithium into the bottle (the air in the injector must be replaced with argon, which must then be expelled when collecting the N-Butyllithium; fill and drain the injector in the N-Butyllithium multiple times to prevent any water or air from remaining in the injector). The system should turn a purplish red. Then, wash, dry, and rinse the same injector with titration solution 2-3 times (to prevent any change in the amount added) and titrate the solution until the system turns yellow, and cease titration.
5) Repeat titration once; if the percent error between the two times is within 2%, the result can be regarded as correct.
6) Titration result: titration solution (ml)/2 to obtain N-Butyllithium concentration.
Warnings and precautions
1) N-Butyllithium is extremely combustible when in contact with air; when measuring, the needle of the injector will eject sparks.
2) The entire process must be protected by argon for safety precaution.
3) If N-Butyllithium catches fire, it must be extinguished with sand, which must be placed within arm’s reach at all times.
When preparing and using N-Butyllithium, do not operate alone in case of emergency
Category
Spontaneously combustible when in contact with water
Explosivity characteristics
May explode in combination with phenylethylene
Flammability characertistics
Combusts in air at a concentration abover 20%; combusts upon contact with water and carbon dioxide; flammable when in contact with heat and open flame.
Storage
Store in ventilated, cool and dry spaces; must be waterproof and carbon dioxide-proof.
Extinguisher
Dry powder

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