ChemicalBook CAS DataBase List 105462-24-6

105462-24-6

Name	Risedronic acid
CAS	105462-24-6
EINECS(EC#)	600-654-2
Molecular Formula	C7H11NO7P2
MDL Number	MFCD00867080
Molecular Weight	283.11
MOL File	105462-24-6.mol

Chemical Properties

Melting point	>232°C (subl.)
Boiling point	692.3±65.0 °C(Predicted)
density	1.870±0.06 g/cm3(Predicted)
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	Aqueous Base (Slightly), Methanol (Very Slightly, Heated, Sonicated)
form	Solid
pka	1.41±0.10(Predicted)
color	White to Off-White
Stability:	Hygroscopic
InChI	InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15)
InChIKey	IIDJRNMFWXDHID-UHFFFAOYSA-N
SMILES	C(P(=O)(O)O)(P(=O)(O)O)(O)CC1=CC=CN=C1
CAS DataBase Reference	105462-24-6(CAS DataBase Reference)
EPA Substance Registry System	Phosphonic acid, P,P'-[1-hydroxy-2-(3-pyridinyl)ethylidene]bis- (105462-24-6)

Safety Data

Hazardous Substances Data

105462-24-6(Hazardous Substances Data)

Hazard Information

Uses

Risedronic acid is a potentially useful biophosphonate for bone resorption analysis.

Uses

Risedronic Acid is a pyridinyl biphosphonate bone resorption inhibitor.

Definition

ChEBI: Risedronic acid is a member of pyridines. It is a third generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease. It functions by preventing resorption of bone.

in vivo

Risedronic acid (Risedronate) (30 μg/kg; subcutaneous injection; once every other day; 3 weeks) prevents radiation-induced osteoporosis in female C57BL/6 mice irradiated with 2 Gy X-rays, inhibits trabecular bone loss and microstructural damage, and suppresses the increase in osteoclast number and serum TRAP5b².
Risedronic acid (10-25 mg/kg; intraperitoneal injection; once a day; 7 days) inhibits parasitemia in BALB/c mice infected with?Plasmodium berghei?strain ANKA, but does not prolong the survival time of mice³.

Animal Model:	Female C57BL/6 mice (20-week-old, ~23 g) irradiated with 2 Gy X-rays whole-body²
Dosage:	30 μg/kg
Administration:	Subcutaneous injection, once every other day, for 3 weeks
Result:	Prevented the radiation-induced increase in osteoclast number, surface, and TRAP5b.

Animal Model:	Male BALB/c mice (3-4 weeks old) infected with?Plasmodium berghei?strain ANKA by intraperitoneal injection of?1×10⁶?blood-stage parasites³
Dosage:	10 mg/kg, 15 mg/kg, 20 mg/kg, 25 mg/kg
Administration:	Intraperitoneal injection, once a day, for 7 days
Result:	Led to an 88.9% inhibition of the rodent parasite Plasmodium berghei in mice on the seventh day of treatment.

storage

Store at -20°C

Mode of action

Risedronatic acid binds to bone hydroxyapatite. Bone resorption causes local acidification, releasing risedronic acid which is that taken into osteoclasts by fluid-phase endocytosis. Endocytic vesicles are acidified, releasing risedronic acid to the cytosol of osteoclasts where they induce apoptosis through inhbition of farnesyl pyrophosphate synthase. Inhibition of osteoclasts results in decreased bone resorption.

Spectrum Detail

Supplier

changzhoubaotuobiochemical&pharm、LTD.

Telephone0519-13912326059 13912326059

Websitehttps://www.czbtchem.com

Shanghai Boyle Chemical Co., Ltd.

Telephone 021-50182298 021-50180596

Websitehttp://www.boylechem.com

J & K SCIENTIFIC LTD.

Telephone18210857532; 18210857532

Websitehttps://www.jkchemical.com

BeiJing Hwrk Chemicals Limted

Telephone0757-86329057 18934348241

Websitehttp://www.hwrkchemical.com/

Energy Chemical

Telephone021-021-58432009 400-005-6266

Websitehttp://www.energy-chemical.com

Capot Chemical Co., Ltd

Telephone+86 (0) 571 85 58 67 18

Websitehttp://www.capotchem.com/

JinYan Chemicals(ShangHai) Co.,Ltd.

Telephone13817811078

Websitehttp://www.jingyan-chemical.com/

Jia Xing Isenchem Co.,Ltd

Telephone0573-85285100 18627885956

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm

Adamas Reagent, Ltd.

Telephone400-6009262 16621234537

Websitehttp://www.tansoole.com

Shanghai Longsheng chemical Co.,Ltd.

Telephone021-58099652-8005 13585536065

Websitehttp://www.shlschem.com

XiaoGan ShenYuan ChemPharm co,ltd

Telephone 15527621225

Websitehttp://www.farchem.com/

Tianjin heowns Biochemical Technology Co., Ltd.

Telephone400 638 7771

Websitehttp://www.heowns.com

Hangzhou Yuhao Chemical Technology Co., Ltd

Telephone0571-82693216

Websitehttp://www.chemyuhao.com

ZhengZhou HuaWen Chemical Co.Ltd

Telephone0370-2785118 17550508557

Websitehttp://www.hnhwchem.com

Suzhou Sibian Chemical Technology Co.,Ltd.

Telephone0512-65617459 18915409046

Websitehttp://www.sibian-chem.com

Beijing HuaMeiHuLiBiological Chemical

Telephone010-56205725

Websitehttp://www.huabeibiochem.com/

Shanghai T&W Pharmaceutical Co., Ltd.

Telephone+86 21 61551611

Websitehttp://www.trustwe.com

Haoyuan Chemexpress Co., Ltd.

Telephone021-58950125

Websitehttp://gb.chemexpress.com.cn

1of4

Related Products

Send Inquriy