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59-30-3

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Identification

Name
Folic acid
CAS
59-30-3
Synonyms
ACIDUM FOLICUM
CYTOFOL
FOLACIN
FOLIC ACID
FOLIC ACID HYDRATE
FOLSAN
FOLSAURE
INCAFOLIC
l-pteroylglutamic acid
n-4-[(2-amido-4-oxo-1,4-dihydro-6-terene)methylamino]benzoyl-l-glutamic acid
N-[4-[[(2-AMINO-4-HYDROXY-6-PTERIDYL)METHYL]AMINO]BENZOYL]GLUTAMIC ACID
PGA
PTEGLU
PTEROYGLUTAMIC ACID
PTEROYLGLUTAMIC ACID
PTEROYL-L-GLUTAMIC ACID
PTEROYLMONOGLUTAMIC ACID
Vitamin B11
VITAMIN BC
VITAMIN M
EINECS(EC#)
200-419-0
Molecular Formula
C19H19N7O6
MDL Number
MFCD00079305
Molecular Weight
441.4
MOL File
59-30-3.mol

Chemical Properties

Appearance
orange to yellow crystalline powder
mp 
250 °C
alpha 
20 º (c=1, 0.1N NaOH)
storage temp. 
2-8°C

Stability:
Stable. Incompatible with heavy metal ions, strong oxidizing agents, strong reducing agents. Solutions may be light and heat sensitive.
Water Solubility 
1.6 mg/L (25 ºC)
Merck 
4221
Uses
Folic Acid is a water-soluble b-complex vitamin that aids in the for- mation of red blood cells, prevents certain anemias, and is essential in normal metabolism. high-temperature processing affects its sta- bility. it is best stored at lower than room temperatures. it is also termed folacin. it is found in liver, nuts, and green vegetables.
Uses
folic acid is generally used as an emollient. In vitro and in vivo skin studies now indicate its capacity to aid in DnA synthesis and repair, promote cellular turnover, reduce wrinkles, and promote skin firmness. There is some indication that folic acid may also protect DnA from uV-induced damage. Folic acid is a member of the vitamin B complex and is naturally occurring in leafy greens.
Uses
Literature tends to indicate that B vitamins cannot pass through the layers of the skin and, therefore, are of no value in the skin surface. Current experiments demonstrate, however, that vitamin B2 acts as a chemical reaction accelerator, enhancing the performance of tyrosine derivatives in suntan-accelerating preparations.
CAS DataBase Reference
59-30-3(CAS DataBase Reference)
NIST Chemistry Reference
Folic acid(59-30-3)
EPA Substance Registry System
59-30-3(EPA Substance)

Safety Data

Risk Statements 
R33:Danger of cumulative effects.
R62:Possible risk of impaired fertility.
R68:Possible risk of irreversible effects.
Safety Statements 
S24/25:Avoid contact with skin and eyes .
WGK Germany 
1

RTECS 
LP5425000


8
HS Code 
29362910
Safety Profile
Poison by intraperitoneal and intravenous routes. Experimental teratogenic effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Hazardous Substances Data
59-30-3(Hazardous Substances Data)

Raw materials And Preparation Products

Hazard Information

General Description
Odorless orange-yellow needles or platelets. Darkens and chars from approximately 482°F.
Reactivity Profile
Acid solutions of FOLIC ACID(59-30-3) are sensitive to heat, but towards neutrality, stability progressively increases. Solutions are inactivated by ultraviolet light and alkaline solutions are sensitive to oxidation. FOLIC ACID(59-30-3) is also inactivated by light. This chemical is incompatible with oxidizing agents, reducing agents and heavy metal ions.
Air & Water Reactions
Insoluble in water. Aqueous solutions have pHs of 4.0-4.8.
Fire Hazard
Flash point data for this chemical are not available; however, FOLIC ACID is probably combustible.

Material Safety Data Sheet(MSDS)

Questions And Answer

Description
Folic acid (folate) is a kind of B-vitamin which is mainly present in the liver and kidney. It has various kinds of pharmacological and physiological effects. It is involved in amino acid metabolism, purine and pyrimidine synthesis, and is also essential for hematopoiesis and red blood cell generation. In women pregnancy, folate can effectively prevent neural tube defects in the baby. It plays important role in fertility through contributing to spermatogenesis. It can also reduce the incidence of heart disease, stroke and cancer. 
Folate deficiency may lead to various kinds of diseases including glossitis, diarrhea, depression, confusion, anemia, and fetal neural tube defectsand brain defects (during pregnancy). Other symptoms may include fatigue, gray hair, mouth sores, poor growth, and swollen tongue.

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