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Name Folic acid
CAS 59-30-3
EINECS(EC#) 200-419-0
Molecular Formula C19H19N7O6
MDL Number MFCD00079305
Molecular Weight 441.4
MOL File 59-30-3.mol

Chemical Properties

Appearance orange to yellow crystalline powder
Melting point  250 °C
alpha  20 º (c=1, 0.1N NaOH)
Boiling point  552.35°C (rough estimate)
density  1.4704 (rough estimate)
refractive index  1.6800 (estimate)
storage temp.  2-8°C
solubility  boiling water: soluble1%
form  Crystalline Powder
pka pKa 2.5 (Uncertain)
color  Yellow to orange
Odor Odorless
PH Range 4
Stability: Stable. Incompatible with heavy metal ions, strong oxidizing agents, strong reducing agents. Solutions may be light and heat sensitive.
Water Solubility  1.6 mg/L (25 ºC)
Merck  4221
BRN  100781
BCS Class 3
LogP -0.990 (est)
folic acid is generally used as an emollient. In vitro and in vivo skin studies now indicate its capacity to aid in DnA synthesis and repair, promote cellular turnover, reduce wrinkles, and promote skin firmness. There is some indication that folic acid may also protect DnA from uV-induced damage. Folic acid is a member of the vitamin B complex and is naturally occurring in leafy greens.
CAS DataBase Reference 59-30-3(CAS DataBase Reference)
NIST Chemistry Reference Folic acid(59-30-3)
EPA Substance Registry System 59-30-3(EPA Substance)

Safety Data

Risk Statements 
R33:Danger of cumulative effects.
R62:Possible risk of impaired fertility.
R68:Possible risk of irreversible effects.
Safety Statements 
S24/25:Avoid contact with skin and eyes .
WGK Germany  1
RTECS  LP5425000
HS Code  29362910
Safety Profile
Poison by intraperitoneal and intravenous routes. Experimental teratogenic effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Hazardous Substances Data 59-30-3(Hazardous Substances Data)
A water soluble vitamin required in the diet of mammals. Sulfonamide drugs are selectively toxic to bacteria because they inhibit the incorporation of p-aminobenzoic acid into folic acid, a biosynthetic process in bacteria. Folic acid deficiency adversely affects prenatal development in humans. Dietary supplementation with folic acid dramatically reduces the incidence of neural tube defects in humans. Folic acid deficiency may also contribute to the causes of megaloblastic macrocytic anemia and a consequence of this is that this disease can be induced, as a side effect, when methotrexate, a folic acid antagonist, is used in cancer chemotherapy

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