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ChemicalBook > CAS DataBase List > Parthenolide

Parthenolide

  • $30 - $247
  • Product name:Parthenolide
  • CAS:20554-84-1
  • MF: C15H20O3
  • MW:248.32
  • EINECS:692-532-0
  • MDL Number:MFCD00134592
  • Synonyms:Parthenolide, Tanacetum parthenium - CAS 20554-84-1 - Calbiochem;Factory Price Parthenolide 20554-84-1;Natural Plant Extracts Parthenolide 20554-84-1 High Purity HPLC>98%;Feverfew P.E Parthenlide;[1aR-(1aR*,4E,7aS*,10aS*,-10bR*)]-2,3-6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one;(1aR,4E,7aS,10aS,10bS)-2,3,6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one;4,5α-Epoxy-6β-hydroxygermacra-1(10),11(13)-dien-12-oic acid γ-lactone;4,5alpha-epoxy-6beta-hydroxy-germacra-1(10),11(13)-dien-12-oic acid gamma-lactone
Price
  • Brand:Sigma-Aldrich
  • Product number:P0667
  • Product nameParthenolide
  • Purity:≥98% (HPLC)
  • Packaging:25mg
  • Price:$176
  • Updated:2020/8/18 13:37:41
  • Buy:Buy
  • Brand:Sigma-Aldrich
  • Product number:1500400
  • Product nameParthenolide
  • Purity:United States Pharmacopeia (USP) Reference Standard
  • Packaging:25mg
  • Price:$176
  • Updated:2020/8/18 13:37:41
  • Buy:Buy
  • Brand:Sigma-Aldrich
  • Product number:P0667
  • Product nameParthenolide
  • Purity:≥98% (HPLC)
  • Packaging:5mg
  • Price:$50.6
  • Updated:2020/8/18 13:37:41
  • Buy:Buy
  • Brand:TCI Chemical
  • Product number:P1982
  • Product nameParthenolide
  • Purity:>97.0%(HPLC)
  • Packaging:25mg
  • Price:$83
  • Updated:2021/3/22 18:33:11
  • Buy:Buy
  • Brand:TCI Chemical
  • Product number:P1982
  • Product nameParthenolide
  • Purity:>97.0%(HPLC)
  • Packaging:100mg
  • Price:$247
  • Updated:2021/3/22 18:33:10
  • Buy:Buy
Properties
  • Melting point:115-116 °C (lit.)
  • alpha D20 -81.4° (c = 1.04 in chloroform); D22 -71.4° (c = 0.220 in CH2Cl2)
  • Boiling point:394.1±42.0 °C(Predicted)
  • Density 1.13±0.1 g/cm3(Predicted)
  • storage temp. -20°C
  • form White solid
  • Merck 14,7048
  • CAS DataBase Reference20554-84-1
Safety Information
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Description

Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium). It inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 μg/ml). Parthenolide also induces apoptosis in cancer cells, at least in part by inhibiting NF-κB- and STAT-mediated anti-apoptotic gene transcription. This compound has also been shown to block inflammation by inhibiting signaling through NF-κB. Inhibition of NF-κB by parthenolide can be achieved by direct binding of the pattern recognition receptor NOD2 by parthenolide.


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