Technical Data Sheet (TDS)
Product Name: Parthenolide
CAS Number: 20554-84-1
Molecular Formula: C15H20O3
Molecular Weight: 248.32 g/mol
1. Description
Parthenolide is a naturally occurring sesquiterpene lactone found in the plant Tanacetum parthenium (feverfew). It is known for its biological activity, including anti-inflammatory, antioxidant, and potential anti-cancer effects.
Appearance: Pale yellow crystalline powder
Odor: Characteristic, slightly herbal
Taste: Bitter
2. Specifications
| Test Item | Specification |
|---|
| Appearance | Pale yellow crystalline powder |
| Odor | Characteristic, slight herbal |
| Identification | TLC/ HPLC consistent with reference standard |
| Assay (on dry basis) | ≥ 98% |
| Loss on Drying | ≤ 1.0% |
| Heavy Metals | ≤ 10 ppm |
| Lead (Pb) | ≤ 2 ppm |
| Arsenic (As) | ≤ 1 ppm |
| Cadmium (Cd) | ≤ 1 ppm |
| Mercury (Hg) | ≤ 0.1 ppm |
| Residual Solvents | Compliant with USP/EP |
| Microbiological Quality | Total Plate Count ≤ 1000 cfu/g |
| Yeast & Mold | ≤ 100 cfu/g |
| E. coli | Negative |
| Salmonella | Negative |
3. Physical & Chemical Properties
Melting Point: 109–112°C
Solubility: Practically insoluble in water; soluble in ethanol, DMSO, chloroform
Optical Rotation: [α]D^20 = –50° (c = 1, ethanol)
Stability: Stable under normal conditions; protect from light, heat, and moisture
4. Applications
Food & Nutraceutical Industry
Can be used as an active ingredient in dietary supplements and herbal formulations targeting anti-inflammatory and antioxidant effects.
Typical dosage in supplements: 0.1–1 mg/day, depending on formulation and regulatory approval.
Not used as a direct food additive; generally incorporated in standardized extracts.
Industrial & Research Applications
Widely used in pharmacological and biomedical research for studying anti-inflammatory, anticancer, and other bioactivities.
Employed in extraction and synthesis of related sesquiterpene lactones.
Suitable for formulation of laboratory-grade reagents.
5. Storage & Handling
Store in a cool, dry place away from light and moisture.
Keep container tightly closed.
Use personal protective equipment when handling pure powder.
6. Regulatory Status
For food/nutraceutical use, must comply with local dietary supplement regulations.
For industrial/research use, handled according to laboratory chemical safety standards.
7. Shelf Life
24 months when stored properly in original, unopened packaging.
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