Supplier Related Products Identification Chemical Properties Hazard Information Safety Data
WebSite >  CAS DataBase List  > 20554-84-1

20554-84-1

Supplier Related Products Identification Chemical Properties Hazard Information Safety Data

Product Image

Identification

Name
Parthenolide
CAS
20554-84-1
Synonyms
PTL
Nsc157035
Aids007764
Parthelide
Aids-007764
Parthenolide
PartheNAlide
Parthenolides
Parthenolide(PTL)
Parthenolide (25 mg)
Parthenolide ((-)-Parthenolide)
PARTHENOLIDE, TANACETUM PARTHENIUM
Parthenolide from Chrysanthenum parthenium
Oxireno(9,10)cyclodeca(1,2-B)furan-9(1ah)-o
Parthenolide, froM ChrysantheMuM MorifoliuM
Parthenolide, 98%, from Chrysanthemum morifolium
4,5α-Epoxy-6β-hydroxygermacra-1(10),11(13)-dien-12-oic acid γ-lactone
4,5-alpha-epoxy-6-beta-hydroxy-11(13)-dien-12-oicacigamma-germacra-1(10
4,5-alpha-epoxy-6-beta-hydroxygermacra-1(10),11(13)-dien-12-oicacidgamma-la
4,5alpha-epoxy-6beta-hydroxy-germacra-1(10),11(13)-dien-12-oic acid gamma-lactone
Germacra-1(10),11(13)-dien-12-oic acid, 4,5-alpha-epoxy-6-beta-hydroxy-, gamma-lactone
(1aR,4E,7aS,10aS,10bS)-2,3,6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
Oxireno9,10cyclodeca1,2-bfuran-9(1aH)-one, 2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-8-methylene-, (1aR,4E,7aS,10aS,10bR)-
Oxireno[9,10]cyclodeca[1,2-B]furan-9(1ah)-one, 2,3,6,7,7A,8,10A,10B-octahydro-1A,5-dimethyl-8-methylene-, (1ar,4E,7as,10as,10bs)-
(3aS,9aR,10aS,10bS,E)-6,9a-dimethyl-3-methylene-3a,4,5,8,9,9a,10a,10b-octahydrooxireno[2',3':9,10]cyclodeca[1,2-b]furan-2(3H)-one
[1AR-(1AR*,4E,7AS*,10AS*-10BR*)]-2,3-6,7,7A,8,10A,10B-OCTAHYDRO-1A,5-DIMETHYL-8-METHYLENEOXIRENO[9,10]CYCLODECA[1,2-B]FURAN-9(1AH)-ONE
[1aR-(1aR*,4E,7aS*,10aS*,-10bR*)]-2,3-6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
EINECS(EC#)
1592732-453-0
Molecular Formula
C15H20O3
MDL Number
MFCD00134592
MOL File
20554-84-1.mol
Molecular Weight
248.32

Chemical Properties

Melting point 
115-116 °C(lit.)

Boiling point 
394.1±42.0 °C(Predicted)
alpha 
D20 -81.4° (c = 1.04 in chloroform); D22 -71.4° (c = 0.220 in CH2Cl2)
density 
1.13±0.1 g/cm3(Predicted)
storage temp. 
2-8°C

form 
White solid
Merck 
14,7048
Contact allergens
Parthenolide is a sesquiterpene lactone found Asteraceae- Compositae such as feverfew (Tanacetum parthenium Schultz-Bip.) or congress grass (Parthenium hysterophorus L.).
CAS DataBase Reference
20554-84-1

Hazard Information

Chemical Properties
White solid
Uses
Antiinflammatory;MAP kinase inhibitor
Definition
ChEBI: A sesquiterpene lactone and active principle of Feverfew (Tanacetum parthenium).
Uses
Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium). It inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 μg/ml). Parthenolide also induces apoptosis in cancer cells, at least in part by inhibiting NF-κBand STAT-mediated anti-apoptotic gene transcription. This compound has also been shown to block inflammation by inhibiting signaling through NF-κB. Inhibition of NF-κB by parthenolide can be achieved by direct binding of the pattern recognition receptor NOD2 by parthenolide.
Biological Activity
The active principle of feverfew (Chrysanthemum parthenium), widely used as a herbal remedy for arthritis and migraine and as a febrifuge. Parthenolide is antisecretory, anti-inflammatory, spasmolytic and inhibits the release of 5-HT from blood platelets. Also inhibits generation of leukotriene B 4 and thromboxane B 2 .
Description
Parthenolide is an allergen in feverfew (Tanacetum parthenarium).
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biochem/physiol Actions
Parthenolide is a sesquiterpene lactone present abundantly in the leaves and flowers of Tanacetum parthenium. It exhibits anti-cancer properties for the treatment of invasive cancers. Parthenolide exhibits therapeutic effects against inflammation and migraine. It plays a role in signal transduction and activation of transcription (STAT)-inhibition-mediated transcriptional repression of pro-apoptotic genes.

Safety Data

Hazard Codes 
Xi,C,F
Risk Statements 
11-34
Safety Statements 
22-24/25-45-36/37/39-26-16
WGK Germany 
3

RTECS 
LY4220000

HS Code 
29322090
SupplierMore