Дифлунисал
- английское имяDiflunisal
- CAS №22494-42-4
- CBNumberCB9674965
- ФормулаC13H8F2O3
- мольный вес250.2
- EINECS245-034-9
- номер MDLMFCD00057834
- файл Mol22494-42-4.mol
химическое свойство
| Температура плавления | 207-209?C |
| Температура кипения | 386.9±42.0 °C(Predicted) |
| плотность | 1.3505 (estimate) |
| температура хранения | Keep in dark place,Sealed in dry,Room Temperature |
| растворимость | Practically insoluble in water, soluble in ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides. |
| форма | Solid |
| пка | pKa 3.3 (H2O I=0.1) (Uncertain) |
| цвет | White |
| Растворимость в воде | 6.186mg/L(24.99 ºC) |
| Справочник по базе данных CAS | 22494-42-4(CAS DataBase Reference) |
| Рейтинг продуктов питания EWG | 1 |
| FDA UNII | 7C546U4DEN |
| Предложение 65 Список | Diflunisal |
| Словарь наркотиков NCI | diflunisal |
| Код УВД | N02BA11 |
| Справочник по химии NIST | Diflunisal(22494-42-4) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
| Коды опасности | Xn,Xi | |||||||||
| Заявления о рисках | 22-36/37/38-63 | |||||||||
| Заявления о безопасности | 22-26-36 | |||||||||
| WGK Германия | 3 | |||||||||
| RTECS | DV2030000 | |||||||||
| Примечание об опасности | Irritant | |||||||||
| кода HS | 2918290000 | |||||||||
| Токсичность | LD50 orally in female mice: 439 mg/kg (Stone) | |||||||||
| NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H315：При попадании на кожу вызывает раздражение.
H319：При попадании в глаза вызывает выраженное раздражение.
H335：Может вызывать раздражение верхних дыхательных путей.
H302：Вредно при проглатывании.
H361：Предполагается, что данное вещество может отрицательно повлиять на способность к деторождению или на неродившегося ребенка.
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оператор предупредительных мер
P201：Беречь от тепла, горячих поверхностей, искр, открытого огня и других источников воспламенения. Не курить.
P301+P312+P330：ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии. Прополоскать рот.
P302+P352：ПРИ ПОПАДАНИИ НА КОЖУ: Промыть большим количеством воды.
P305+P351+P338：ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз.
P308+P313：ПРИ подозрении на возможность воздействия обратиться за медицинской помощью.
Дифлунисал химические свойства, назначение, производство
Описание
Diflunisal is more potent than aspirin but produces fewer side effects and has a biological half-life three to four times greater than that of aspirin. It is rapidly and completely absorbed on oral administration, with peak plasma levels being achieved within 2 to 3 hours of administration. It is highly bound (99%) to plasma proteins after absorption. Its elimination half-life is 8 to 12 hours, and it is excreted into urine primarily as glucuronide conjugates. The most frequently reported side effects include disturbances of the GI system (e.g., nausea, dyspepsia, and diarrhea), dermatological reactions, and CNS effects (e.g., dizziness and headache).Химические свойства
White SolidИспользование
As a prostaglandin synthetase inhibitor, diflunisal exhibits analgesic, fever-reducing, and anti-inflammatory action. It is used for long- and short-lasting symptomatic relief of low to moderate pain in osteoarthritis and rheumatoid arthritis.Общее описание
Diflunisal (Dolobid), is a longer acting and more potent drugthan aspirin because of its hydrophobic, 2,4-difluorophenylgroup attached to the 5-position of the salicyclic acid. In alarge-scale comparative study with aspirin, it was also bettertolerated with less GI complications than aspirin. It ismarketed in tablet form for treating mild to moderate postoperativepain as well as RA and OA.Diflunisal is highly protein bound. Its metabolism is subjectto a dose-dependent, saturable, and capacity-limitedglucuronide formation. This unusual pharmacokineticprofile is a result of an enterohepatic circulation and the reabsorptionof 65% of the drug and its glucuronides, followedby cleavage of its unstable, acyl glucuronide back tothe active drug. Thus, diflunisal usage in patients with renalimpairment should be closely monitored.
Фармакокине?тика
Diflunisal is more potent than aspirin but produces fewer side effects and has a biological half-life three to four times greater than that of aspirin. It is rapidly and completely absorbed on oral administration, with peak plasma levels being achieved within 2 to 3 hours of administration. It is highly bound (99%) to plasma proteins after absorption. Its elimination half-life is 8 to 12 hours, and it is excreted into urine primarily as glucuronide conjugates. The most frequently reported side effects include disturbances of the GI system (e.g., nausea, dyspepsia, and diarrhea), dermatological reactions, and CNS effects (e.g., dizziness and headache).Клиническое использование
Diflunisal (pKa 3.3) was introduced in the United States in 1982 and has gained considerable acceptance as an analgetic and as a treatment of rheumatoid arthritis and osteoarthritis. Diflunisal is metabolized primarily to ether and ester glucuronide conjugates.Профиль безопасности
Poison by ingestion, subcutaneous, and intraperitoneal routes. Human systemic effects by ingestion: tolerance, and cholestatic jaundce (due to the stoppage of the flow of bile), agranulocytosis, increased body temperature. An experimental teratogen. Other experimental reproductive effects. An analgesic and anti-inflammatory agent. When heated to decomposition it emits toxic fumes of F-. See also FLUORIDES.Дифлунисал запасные части и сырье
Дифлунисал поставщик
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