Фуразолидон
- английское имяFurazolidone
- CAS №67-45-8
- CBNumberCB8452405
- ФормулаC8H7N3O5
- мольный вес225.16
- EINECS200-653-3
- номер MDLMFCD00010550
- файл Mol67-45-8.mol
химическое свойство
| Температура плавления | 254-256°C (dec.) |
| Температура кипения | 366.66°C (rough estimate) |
| плотность | 1.5406 (rough estimate) |
| показатель преломления | 1.7180 (estimate) |
| Fp | 2 °C |
| температура хранения | Keep in dark place,Sealed in dry,Room Temperature |
| растворимость | formic acid: soluble50mg/mL |
| пка | -1.98±0.20(Predicted) |
| форма | powder |
| цвет | yellow |
| Чувствительный | Light Sensitive |
| λмакс | 365nm(DMSO)(lit.) |
| Мерк | 14,4300 |
| БРН | 8317414 |
| Стабильность | Stable. Combustible. Incompatible with strong oxidizing agents. |
| ИнЧИКей | PLHJDBGFXBMTGZ-UITAMQMPSA-N |
| FDA 21 CFR | 530.41 |
| Рейтинг продуктов питания EWG | 1 |
| FDA UNII | 5J9CPU3RE0 |
| Предложение 65 Список | Furazolidone |
| Словарь наркотиков NCI | furazolidone |
| Код УВД | G01AX06 |
| Справочник по химии NIST | Furazolidone(67-45-8) |
| МАИР | 3 (Vol. 31, Sup 7) 1987 |
| Система регистрации веществ EPA | Furazolidone (67-45-8) |
больше
| Коды опасности | Xn,F | |||||||||
| Заявления о рисках | 62-40-36-20/21/22-11-68 | |||||||||
| Заявления о безопасности | 36-22-36/37-16 | |||||||||
| WGK Германия | 3 | |||||||||
| RTECS | RQ3675000 | |||||||||
| TSCA | Yes | |||||||||
| кода HS | 29349990 | |||||||||
| Банк данных об опасных веществах | 67-45-8(Hazardous Substances Data) | |||||||||
| NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H361：Предполагается, что данное вещество может отрицательно повлиять на способность к деторождению или на неродившегося ребенка.
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оператор предупредительных мер
P280：Использовать перчатки/ средства защиты глаз/ лица.
Фуразолидон химические свойства, назначение, производство
Описание
Furazolidone belongs to the group of nitro furans. This antimicrobal (antibacterial and antiprotozoal) agent is used in veterinary medicine both topically and orally, particularly in animal feed. Reactions have been reported in workers exposed to it by contact with animal feed. Cross reactions with other nitrofuran derivatives are rare.Химические свойства
solidИспользование
The minimum inhibitory concentration of furazolidone was assessed to study the nonreplicating persistence of M. tuberculosis in aerobic and anaerobic conditions using luminescence-based low-oxygen-recovery assay.Определение
ChEBI: A member of the class of oxazolidines that is 1,3-oxazolidin-2-one in which the hydrogen attached to the nitrogen is replaced by an N-{[(5-nitro-2-furyl)methylene]amino} group. It has antibacterial and antiprotozoal properties, and is us d in the treatment of giardiasis and cholera.Всемирная организация здравоохранения(ВОЗ)
Furazolidone, a nitrofuran derivative with antibacterial and antiprotozoal activity, was introduced in 1954. In the 1970s it was shown to have a carcinogenic potential following long-term administration to experimental animals. However, the relevance of this to short-term therapy in man has not been established. The risk-benefit assessment varies and furazolidone remains widely available in many countries for the treatment of diarrhoea and enteritis.Антимикробная активность
It is active against a wide range of enteric pathogens, including Salmonella enterica, Shigella spp., enterotoxigenic Escherichia coli, Campylobacter jejuni, Aeromonas hydrophila, Plesiomonas shigelloides, Vibrio cholerae and V. parahaemolyticus. Yersinia enterocolitica is intrinsically resistant. Furazolidone is also active against the protozoa Giardia lamblia and Trichomonas vaginalis.Приобретенная устойчивость
Acquired resistance has been observed in V. cholerae O1 and O139, S. enterica serotypes Typhi and Enteritidis, A. hydrophila and Shigella spp. Such resistance may be transferable, and there is cross-resistance with nitrofurantoin. Many of these reports come from the Indian subcontinent, where furazolidone is used widely for treating diarrheal diseases.Общее описание
Furazolidone is an effective antiprotozoal and antibacterial agent.Опасность
A questionable carcinogen, use has been restricted.Фармацевтические приложения
A non-ionic synthetic compound, available for oral use only. It is poorly soluble in water (40 mg/L) and ethanol (90 mg/L), but dissolves well in dimethylformamide (10 g/L). It decomposes in the presence of alkali.Контактные аллергены
Furazolidone belongs to the group of nitrofurans. This antimicrobial (antibacterial and antiprotozoal) agent is used in veterinary medicine both topically and orally, particularly in animal feed. Reactions are reported in workers exposed to it in animal feeds. Cross-reactions with other nitrofuran derivatives are rare.Фармакокине?тика
There is substantial absorption (65–70%) after oral administration, but the drug is heavily metabolized, so that only about 5% of the material excreted is microbiologically active. A dose of 5 mg/kg achieves a maximum plasma concentration of around 1 mg/L. Protein binding is about 30%. Intact drug can be found in various body fluids in concentrations approximating to the minimum inhibitory concentration (MIC) for various intestinal pathogens. Less than 1% of the drug is excreted into urine.Клиническое использование
Furazolidone is used in gastrointestinal infections and vaginitis. It is mainly used in developing countries to treat diarrheal diseases of varying etiology, but it is not the drug of choice if a specific pathogen has been identified. Use as a secondline agent in giardiasis and as part of multidrug regimens in Helicobacter infection has been advocated.Побочные эффекты
Most reported side effects are mild and only rarely cause discontinuation of treatment. Nausea and vomiting are experienced by around 8% of patients. Other adverse events include neurological reactions (mainly headache; 1.3% of patients), ‘systemic’ reactions such as fever and malaise (0.6%) and skin rashes (0.54%). Administration of furazolidone may give rise to inhibition of monoamine oxidase, and disulfiram-like reactions have been reported.Профиль безопасности
Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: dyspnea, respiratory depression, and eosinophilta. Experimental reproductive effects. Human mutation data reported. Questionable carcinogen. When heated to decomposition it emits toxic fumes of NOx.Фуразолидон запасные части и сырье
Фуразолидон поставщик
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