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Этаноламин

английское имяMonoethanolamine
CAS №141-43-5
CBNumberCB1218589
ФормулаC2H7NO
мольный вес61.08
EINECS205-483-3
номер MDLMFCD00008183
файл Mol141-43-5.mol

химическое свойство

Температура плавления	10-11 °C(lit.)
Температура кипения	170 °C(lit.)
плотность	1.012 g/mL at 25 °C(lit.)
плотность пара	2.1 (vs air)
давление пара	0.2 mm Hg ( 20 °C)
показатель преломления	n20/D 1.454(lit.)
Fp	200 °F
температура хранения	Store at +15°C to +25°C.
растворимость	Soluble in benzene, ether, carbon tetrachloride.
пка	9.5(at 25℃)
форма	Liquid
цвет	APHA: ≤15
Удельный вес	1.012
Относительная полярность	0.651
РН	12.1 (100g/l, H2O, 20℃)
Запах	ammoniacal odor
Пределы взрываемости	3.4-27%(V)
Растворимость в воде	miscible
Чувствительный	Air Sensitive & Hygroscopic
Мерк	14,3727
БРН	505944
констант закона Генри	1.61(x 10^-10 atm?m³/mol) at 20 °C (Bone et al., 1983)
Диэлектрическая постоянная	31.940000000000001
Пределы воздействия	TLV-TWA 3 ppm (～7.5 mg/m³) (ACGIH, MSHA, and OSHA); TLV-STEL 6 ppm (～15 mg/m³) (ACGIH); IDLH 1000 ppm (NIOSH).
Стабильность	Stable. Flammable; incompatible with strong oxidizing agents, strong acids. Hygroscopic.
ИнЧИКей	HZAXFHJVJLSVMW-UHFFFAOYSA-N
LogP	-2.3--1.91 at 25℃
Вещества, добавляемые в пищу (ранее EAFUS)	MONOETHANOLAMINE
FDA 21 CFR	173.315; 175.105; 176.300; 178.3120
Справочник по базе данных CAS	141-43-5(CAS DataBase Reference)
Рейтинг продуктов питания EWG	3-6
FDA UNII	5KV86114PT
Справочник по химии NIST	Ethanolamine(141-43-5)
Система регистрации веществ EPA	Ethanolamine (141-43-5)
Информация о косметике	Ethanolamine

больше

Заявления об опасности и безопасности

Коды опасности

T,C

Заявления о рисках

20/21/22-34-39/23/24/25-23/24/25-10-52/53

Заявления о безопасности

26-36/37/39-45-61

РИДАДР

UN 2924 3/PG 3

OEB

OEL

TWA: 3 ppm (8 mg/m3), STEL: 6 ppm (15 mg/m3)

WGK Германия

RTECS

KJ5775000

8-10-23

Температура самовоспламенения

410 °C

TSCA

Yes

Класс опасности

Группа упаковки

III

кода HS

29221100

Банк данных об опасных веществах

141-43-5(Hazardous Substances Data)

Токсичность

LD50 orally in rats: 10.20 g/kg (Smyth)

ИДЛА

30 ppm

NFPA 704:

	2
3		0

рисовальное письмо(GHS)

рисовальное письмо(GHS)
сигнальный язык

опасность
вредная бумага

H335：Может вызывать раздражение верхних дыхательных путей.

H314：При попадании на кожу и в глаза вызывает химические ожоги.

H302+H312+H332：Вредно при проглатывании, при попадании на кожу или при вдыхании.

H412：Вредно для водных организмов с долгосрочными последствиями.
оператор предупредительных мер

P273：Избегать попадания в окружающую среду.

P280：Использовать перчатки/ средства защиты глаз/ лица.

P301+P312+P330：ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии. Прополоскать рот.

P303+P361+P353：ПРИ ПОПАДАНИИ НА КОЖУ (или волосы): Снять/удалить немедленно всю загрязненную одежду. Промыть кожу водой.

P304+P340+P312：ПРИ ВДЫХАНИИ: Свежий воздух, покой. Обратиться за медицинской помощью при плохом самочувствии.

P305+P351+P338+P310：ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз. Немедленно обратиться за медицинской помощью.

Этаноламин химические свойства, назначение, производство

Описание

Этаноламин (2-аминоэтанол, тривиальное название коламин) — простейший стабильный аминоспирт, является первичным амином и первичным спиртом. Также называется моноэтаноламином для отличия от диэтаноламина (NH(CH2CH2OH)2) и триэтаноламина (N(CH2CH2OH)3).

Физические свойства

Этаноламин HO-CH2CH2-NH2 (2-аминоэтанол) — органическое соединение, представитель класса аминоспиртов, густая маслянистая жидкость, смешивается с водой во всех отношениях, обладает сильными щелочными свойствами.

Описание

Monoethanolamine is contained in many products, such as metalwork fluids. It is mainly an irritant. Traces may exist in other ethanolamine fluids.

Химические свойства

Monoethanolamine is a clear, colorless or pale yellow-colored, moderately viscous liquid with a mild, ammoniacal odor. Ethanolamines can be detected by odor as low as 2-3 ppm.

Физические свойства

Colorless, viscous, hygroscopic liquid with an unpleasant, mild, ammonia-like odor. Odor threshold concentration is 2.6 ppm (quoted, Amoore and Hautala, 1983). The lowest taste threshold concentration in potable water at 40 °C was 2.4 mg/L (Alexander et al., 1982).

Использование

Monoethanolamine is used as a dispersing agent for agricultural chemicals, in thesynthesis of surface-active agents, as a softening agent for hides, and in emulsifiers,polishes, and hair solutions.

Методы производства

Monoethanolamine is prepared commercially by the ammonolysis of ethylene oxide. The reaction yields a mixture of monoethanolamine, diethanolamine, and triethanolamine, which is separated to obtain the pure products. Monoethanolamine is also produced from the reaction between nitromethane and formaldehyde.

Определение

ChEBI: A member of the class of ethanolamines that is ethane with an amino substituent at C-1 and a hydroxy substituent at C-2, making it both a primary amine and a primary alcohol.

Использование

Моноэтаноламин (МЭА) получают взаимодействием аммиака или водного раствора аммиака с окисью этилена.

ПРИМЕНЕНИЕ: Применяются в технике в качестве эмульгаторов, и других поверхностно-активных веществ, а также в различных процессах газоочистки, в том числе для извлечения углекислого газа из топочных газов при производстве сухого льда, также применяется в процессе обработки древесины, при производстве иминов. Является исходным веществом в промышленном синтезе лекарственного средства таурина.

Общее описание

A clear colorless liquid with an odor resembling that of ammonia. Flash point 185°F. May attack copper, brass, and rubber. Corrosive to tissue. Moderately toxic. Produces toxic oxides of nitrogen during combustion.

Реакции воздуха и воды

Water soluble with evolution of heat.

Профиль реактивности

Ethanolamine is a base. Reacts with organic acids (acetic acid, acrylic acid), inorganic acids (hydrochloric acid, hydrofluoric acid, nitric acid, sulfuric acid, chlorosulfonic acid), acetic anhydride, acrolein, acrylonitrile, cellulose, epichlorohydrin, mesityl oxide, beta-propiolactone, vinyl acetate. Emits toxic fumes of nitrogen oxides when heated to decomposition [Sax, 9th ed., 1996, p. 1498].

Угроза здоровью

Monoethanolamine causes severe irritationof the eyes and mild to moderate irritationof the skin. The pure liquid caused rednessand swelling when applied to rabbits’ skin.The acute oral toxicity of this compound waslow in animals. The toxic symptoms includedsomnolence, lethargy, muscle contraction,and respiratory distress. The oral LD50 valuesshowed a wide variation with species.
LD50 value, oral (rabbits): 1000 mg/kg
Monoethanolamine showed reproductive tox icity when administered at a dose of850 mg/kg/day, causing 16% mortality topregnant animals (Environmental HealthResearch and Testing 1987). This study alsoindicated that monoethanolamine reduced thenumber of viable litters but had no effect onlitter size, the birth weight, or percentage sur vival of the pups.

Пожароопасность

Special Hazards of Combustion Products: Irritating vapors generated when heated.

Фармацевтические приложения

Monoethanolamine is used primarily in pharmaceutical formulations for buffering purposes and in the preparation of emulsions. Other uses include as a solvent for fats and oils and as a stabilizing agent in an injectable dextrose solution of phenytoin sodium.
Monoethanolamine is also used to produce a variety of salts with therapeutic uses. For example, a salt of monoethanolamine with vitamin C is used for intramuscular injection, while the salicylate and undecenoate monoethanolamine salts are utilized respectively in the treatment of rheumatism and as an antifungal agent. However, the most common therapeutic use of monoethanolamine is in the production of ethanolamine oleate injection, which is used as a sclerosing agent.

Контактные аллергены

Monoethanolamine is contained in many products, such as metalworking fluids. It is mainly an irritant. Traces may exist in other ethanolamine fluids.

Профиль безопасности

Poison by intraperitoneal route. Moderately toxic by ingestion, skin contact, subcutaneous, intravenous, and intramuscular routes. A corrosive irritant to skin, eyes, and mucous membranes. Human mutation data reported. Flammable when exposed to heat or flame. A powerful base. Reacts violently with acetic acid, acetic anhydride, acrolein, acrylic acid, acrylonitrile, cellulose, chlorosulfonic acid, epichlorohydrin, HCl, HF, mesityl oxide, HNO3, oleum, H2SO4, p-propiolactone, vinyl acetate. To fight fire, use foam, alcohol foam, dry chemical. When heated to decomposition it emits toxic fumes of NOx. See also AMINES

Безопасность

Monoethanolamine is an irritant, caustic material, but when it is used in neutralized parenteral and topical pharmaceutical formulations it is not usually associated with adverse effects, although hypersensitivity reactions have been reported. Monoethanolamine salts are generally regarded as being less toxic than monoethanolamine.
LD₅₀ (mouse, IP): 0.05 g/kg
LD₅₀ (mouse, oral): 0.7 g/kg
LD₅₀ (rabbit, skin): 1.0 g/kg
LD₅₀ (rat, IM): 1.75 g/kg
LD₅₀ (rat, IP): 0.07 g/kg
LD₅₀ (rat, IV): 0.23 g/kg
LD₅₀ (rat, oral): 1.72 g/kg
LD₅₀ (rat, SC): 1.5 g/kg

Возможный контакт

Monoethanolamine is widely used in industry for scrubbing acid gases and in production of detergents and alkanolamide surfactants; to remove carbon dioxide and hydrogen from natural gas, to remove hydrogen sulfide and carbonyl sulfide; as an alkaline conditioning agent; as an intermediate for soaps, detergents, dyes, and textile agents. Diethanolamine is an absorbent for gases; a solubilizer for 2,4- dichlorophenoxyacetic acid (2,4-D); and a softener and emulsifier intermediate for detergents. It also finds use in the dye and textile industry. Triethanolamine is used as plasticizers, neutralizer for alkaline dispersions; lubricant additive; corrosion inhibitor; and in the manufacture of soaps, detergents, shampoos, shaving preparations; face and hand creams; cements, cutting oils, insecticides, surface active agents; waxes, polishes, and herbicides.

Экологическая судьба

Biological. Bridié et al. (1979) reported BOD and COD values of 0.93 and 1.28 g/g using filtered effluent from a biological sanitary waste treatment plant. These values were determined using a standard dilution method at 20 °C for a period of 5 d. Similarly, Heukelekian and Rand (1955) reported a 5-d BOD value of 0.85 g/g which is 65.0% of the ThOD value of 1.31 g/g.
Chemical/Physical. Aqueous chlorination of ethanolamine at high pH produced Nchloroethanolamine, which slowly degraded to unidentified products (Antelo et al., 1981).
At an influent concentration of 1,012 mg/L, treatment with GAC resulted in an effluent concentration of 939 mg/L. The adsorbability of the carbon used was 15 mg/g carbon (Guisti et al., 1974).

хранилище

Monoethanolamine is very hygroscopic and is unstable when exposed to light. Aqueous monoethanolamine solutions may be sterilized by autoclaving.
When monoethanolamine is stored in large quantities, stainless steel is preferable for long-term storage. Copper, copper alloys, zinc, and galvanized iron are corroded by amines and should not be used for construction of storage containers. Ethanolamines readily absorb moisture and carbon dioxide from the air; they also react with carbon dioxide. This can be prevented by sealing the monoethanolamine under an inert gas. Smaller quantities of monoethanolamine should be stored in an airtight container, protected from light, in a cool, dry place.

Перевозки

UN2491 Ethanol amine or Ethanolamine solutions, Hazard class: 8; Labels: 8-Corrosive material.

Несовместимости

Monoethanolamine contains both a hydroxy group and a primary amine group and will thus undergo reactions characteristic of both alcohols and amines. Ethanolamines will react with acids to form salts and esters. Discoloration and precipitation will take place in the presence of salts of heavy metals. Monoethanolamine reacts with acids, acid anhydrides, acid chlorides, and esters to form amide derivatives, and with propylene carbonate or other cyclic carbonates to give the corresponding carbonates.
As a primary amine, monoethanolamine will react with aldehydes and ketones to yield aldimines and ketimines. Additionally, monoethanolamine will react with aluminum, copper, and copper alloys to form complex salts. A violent reaction will occur with acrolein, acrylonitrile, epichlorohydrin, propiolactone, and vinyl acetate.

Утилизация отходов

Controlled incineration; incinerator equipped with a scrubber or thermal unit to reduce nitrogen oxides emissions

Регуляторный статус

Included in parenteral and nonparenteral medicines licensed in the UK and USA. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

Этаноламин запасные части и сырье

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поставщик	телефон	страна	номенклатура продукции	благоприятные условия
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	China	5894	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	China	20290	58
Qingdao RENAS Polymer Material Co., Ltd.	+86-0532-86867058 +86-18562606086	China	356	58
Hebei Youfeidi Trading Co., LTD	+8615530197691	China	105	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21663	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	China	9276	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32836	60
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +8618949832763	China	2989	55
career henan chemical co	+86-0371-86658258 +8613203830695	China	29888	58

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