Натрия лакта

Описание

Sodium lactate is the sodium salt of lactic acid that has a mild saline taste. It is produced by fermentation of a sugar source, such as corn or beets, and then, by neutralizing the resulting lactic acid to create a compound having the formula NaC₃H₅O₃
As early as 1836, sodium lactate was recognized as a salt of a weak acid rather than being a base, and it was then known that the lactate had to be metabolized in the liver before the sodium could have any titrating activity.

Химические свойства

Sodium lactate occurs as a clear, colorless, slightly syrupy liquid. It is odorless, or has a slight odor with a characteristic saline taste. It is hygroscopic.

Определение

ChEBI: An organic sodium salt having lactate as the counterion.

Общее описание

Sodium DL-lactate is an organic, sodium salt of lactic acid. It is a hygroscopic agent and a component of natural moisturizing factor (NMF). It is usually produced by fermentation.

Фармацевтические приложения

Sodium lactate is widely used in cosmetics, food products and pharmaceutical applications including parenteral and topical formulations.
Therapeutically, sodium lactate is used in infusions as a component of Ringer-lactate solution; as an alternative for sodium hydrogencarbonate in light acidosis; as a rehydrating agent; and as a carrier for electrolyte concentrates or medicines in perfusion/ infusion solutions.

Пищевая добавка

Sodium lactate need not be restricted by someone avoiding milk or those with a milk allergy.In general, lactates such as sodium, calcium, and potassium lactate are salts derived from the neutralization of lactic acid and most commercially used lactic acids are fermented from dairy - free products such as cornstarch, potatoes, or molasses. Sugar or tapioca additionally may be used. However some lactic acid is fermented from dairy products such as whey and lactose . Whey is made of up 6.5 % solids of which 4.8% is solid lactose . Waste whey typically is used to produce lactic acid when the whey itself is produced as waste during the manufacture of certain dairy products . As a result, such dairy-type lactic acid generally goes back into dairy products, such as ice cream and cream cheese, rather than into non - dairy products. Moreover, although the lacticacid starter culture to ferment corn or beets may contain milk, sodium lactate does not contain milk protein and need not be restricted by someone avoiding milk or those with a milk allergy.

Использование

As a food additive, sodium lactate has the E number E325 and is naturally a liquid product, but also is available in powder form. It acts as a preservative, acidity regulator, and bulking agent.
Sodium lactate is sometimes used in shampoo products and other similar items such as liquid soaps as it is an effective humectant and moisturizer.
Sodium lactate is used to treat arrhythmias caused by overdosing of class I antiarrythmics, as well as pressor sympathomimetics which can cause hypertension.
It also can be given intravenously as a source of bicarbonate for preventing or controlling mild to moderate metabolic acidosis in patients with restricted oral intake (for sodium bicarbonate) whose oxidative processes are not seriously impaired. However, the use in lactic acidosis is contraindicated.

Безопасность

Sodium lactate occurs naturally in the body and is involved in physiological processes. It is generally regarded as a relatively nontoxic and nonirritant material when used as an excipient. Low concentrations are well tolerated by skin and eye mucosa, although higher concentrations should be avoided.
LD50 (rat, IP): 2 g/kg

хранилище

Sodium lactate should be stored in a well-closed container in a cool, dry, place. Sodium lactate is combustible and decomposes upon heating.

Регуляторный статус

GRAS listed (not for infant formulas). Included in the FDA Inactive Ingredient Database (epidural, IM, IV, and SC injections; oral suspensions; topical gels and solutions). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.