Пропионат натрия

Описание

Sodium propanoate or sodium propionate is the sodium salt of propionic acid which has the chemical formula Na(C₂H₅COO).

Химические свойства

Colourless crystals or, white or almost white powder, slightly hygroscopic.

Использование

Sodium Propionate is an antimicrobial agent that is the sodium salt of propionic acid. it occurs as colorless, transparent crystals or a gran- ular crystalline powder. it is odorless or has a faint acetic–butyric acid odor, and is deliquescent. it is prepared by neutralizing propionic acid with sodium hydroxide. it is used in baked goods; nonalcoholic beverages; cheeses; confections and frostings; gelatins, puddings, and fillings; jams and jellies; meat products; and soft candy.

Определение

ChEBI: An organic sodium salt comprising equal numbers of sodium and propionate ions.

Реакции

It is produced by the reaction of propionic acid and sodium carbonate or sodium hydroxide.

Биологическая активность

If sodium propionate is ingested or applied topically in an acid media, it becomes propionic acid. It oxidizes fatty acids, lowers pH values, and facilitates the citric acid cycle through interaction with coenzyme A. There has been evidence of heightened production of insulin in cows and sheep; the insulin later settles to an overall lower level. Propionic acid inhibits 14CO2 production from palmitate in both control and methylmalonic fibroblasts; propionic acid also inhibited ureagenesis in rat liver slices. These findings may explain the fatty degeneration of the liver and hyperammonemia in propionic and methylmalonic acidemia. Propionic acidemia is an autosomal recessive disorder caused by a defect of propionyl–coenzyme A carboxylase. The main clinical findings are vomiting, lethargy, hypotonia, and metabolic ketoacidosis, and early clinical onset occurs during the neonatal period in ～80% of the patients.

Профиль безопасности

Moderately toxic by skin contact and subcutaneous routes. Mildly toxic by unspecified routes. An allergen. When heated to decomposition it emits toxic fumes of Na2O.

Методы очистки

Recrystallise it from H2O (solubility 10%) and dry by heating at 100o for 4hours. The solubility of the anhydrous salt in MeOH is 13% at 15o and 13.77% at 68o. It is insoluble in *C6H6 and Me2CO. [Henstock J Chem Soc 1341 1934, Beilstein 2 IV 701.]