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Капсаицин
- английское имяCapsaicin
- CAS №404-86-4
- CBNumberCB6112967
- ФормулаC18H27NO3
- мольный вес305.41
- EINECS206-969-8
- номер MDLMFCD00017259
- файл Mol404-86-4.mol
Температура плавления | 62-65 °C(lit.) |
Температура кипения | 210-220 C |
плотность | 1.1037 (rough estimate) |
показатель преломления | 1.5100 (estimate) |
FEMA | 3404 | CAPSAICIN |
Fp | 113 °C |
температура хранения | 2-8°C |
растворимость | H2O: insoluble |
пка | 9.76±0.20(Predicted) |
форма | Off-white solid |
цвет | Off-white |
Запах | mild warm herbal |
Odor Type | herbal |
Растворимость в воде | insoluble |
Мерк | 14,1768 |
БРН | 2816484 |
Стабильность | Stable. Incompatible with strong oxidizing agents. |
ИнЧИКей | YKPUWZUDDOIDPM-SOFGYWHQSA-N |
LogP | 4.00 |
Вещества, добавляемые в пищу (ранее EAFUS) | N-(4-HYDROXY-3-METHOXYBENZYL)-8-METHYL-6-NONENAMIDE |
FDA 21 CFR | 310.545 |
Справочник по базе данных CAS | 404-86-4(CAS DataBase Reference) |
Рейтинг продуктов питания EWG | 1 |
Словарь онкологических терминов NCI | capsaicin |
FDA UNII | S07O44R1ZM |
Код УВД | M02AB01,N01BX04 |
Система регистрации веществ EPA | Capsaicin (404-86-4) |
Коды опасности | T,T+ | |||||||||
Заявления о рисках | 25-37/38-41-42/43-36/37/38 | |||||||||
Заявления о безопасности | 22-26-28-36/39-45-36/37/39 | |||||||||
РИДАДР | UN 2811 6.1/PG 2 | |||||||||
WGK Германия | 3 | |||||||||
RTECS | RA8530000 | |||||||||
F | 10-21 | |||||||||
Класс опасности | 6.1(a) | |||||||||
Группа упаковки | II | |||||||||
кода HS | 29399990 | |||||||||
Банк данных об опасных веществах | 404-86-4(Hazardous Substances Data) | |||||||||
Токсичность | LD50 oral in mouse: 47200ug/kg | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H315:При попадании на кожу вызывает раздражение.
H335:Может вызывать раздражение верхних дыхательных путей.
H318:При попадании в глаза вызывает необратимые последствия.
H317:При контакте с кожей может вызывать аллергическую реакцию.
H300:Смертельно при проглатывании.
H334:При вдыхании может вызывать аллергическую реакцию (астму или затрудненное дыхание).
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оператор предупредительных мер
P280:Использовать перчатки/ средства защиты глаз/ лица.
P301+P310+P330:ПРИ ПРОГЛАТЫВАНИИ: Немедленно обратиться за медицинской помощью. Прополоскать рот.
P302+P352:ПРИ ПОПАДАНИИ НА КОЖУ: Промыть большим количеством воды.
P305+P351+P338+P310:ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз. Немедленно обратиться за медицинской помощью.
Капсаицин химические свойства, назначение, производство
Описание
Capsaicin has a mild, warm-herbaceous odor and a burning pungent taste (at 10 ppm). It is used in compounded flavors for sauces where the pungent note is desired. This substance is present in several species of Capsicum (Family, Solanaceae). The sensation of pain, accompanied by irritation and inflammation, is due to substance P depletion from sensory (afferent) nerve fibers. These properties are used to study the physiology of pain and the effects as a counterirritant and gastrointestinal stimulant. This substance may be prepared from 3-chloro-2-isopropyltetrahydropyran; biosynthesis from Capsicum frutescens; separation form cis-capsaicin, pelargonic acid vanilamide, and dihydrocapsaicin, reaction of capsaicin.Химические свойства
Off-White Crystalline SolidФизические свойства
Appearance: crystalline white powder, with highly volatile and pungent odor. Solubility: freely soluble in alcohol, ether, benzene, and chloroform; slightly soluble in carbon disulfide, petroleum, and hydrochloric acid; insoluble in water. Melting point: 65?°C.Вхождение
The pungent principle in the fruits of various Capsicum species (Solanaceae)Использование
Capsaicin analogue (C175680). It is used as a tool in neurobiological research. Prototype vanilloid receptor agonist. Topical analgesic.Показания
Capsaicin (Zostrix) is approved for the relief of pain following herpes zoster infection (postherpetic neuralgia). The drug depletes neurons of substance P, an endogenous neuropeptide that may mediate cutaneous pain. It is applied to affected skin after open lesions have healed. Local irritation is common.Общее описание
Capsaicin occurs as the active ingredient of hot/red pepper and was first obtained by Thresh in 1846. It is a lipophilic vanilloid compound responsible for the acrid taste of hot peppers.Биологическая активность
Prototypic vanilloid receptor agonist (pEC 50 values are 7.97 and 7.10 at rat and human VR1 receptors respectively). Excites a subset of primary afferent sensory neurons, with subsequent antinociceptive and anti-inflammatory effects. Reversibly inhibits aggregation of platelets. Also available as part of the Vanilloid TRPV1 Receptor Tocriset™ .разработк И противоопухолевых препаратов
Capsaicin is the major pungent ingredient in red and green chili pepper. It is reportedto induce apoptosis selectively in cancer cells and can suppress the activation ofNF-κB through suppression of NF-κB inhibitor IκBα (Aggarwal and Shishodia 2004). It shows anticancer effects in animal models and suppresses carcinogenesisin colon, skin, lung, tongue, and prostate cancers by altering the metabolism ofcarcinogens. It selectively suppresses the human cancer cell growth of prostate,leukemic, glioma, gastric, and hepatic cancers. It inhibited the tumorigenesis linkedand IL-6-induced activation of STAT-3 and STAT3-regulated gene products likecyclin D1, Bcl-2, Bcl-xL, survivin, and VGEF. It arrests cells in G1 phase andinduces apoptosis (Aggarwal et al. 2008; Clark and Lee 2016).Клиническое использование
In clinical practice, capsaicin is mainly used for topical administration, such as in the treatment of osteoarthritis and rheumatoid arthritis pain, diabetic nerve pain, pain after surgery, chemotherapy- or radiotherapy-induced oral pain, psoriasis, etc. Capsaicin irritates the mucous membrane to cause sneezing, nose bleeding, coughing, mucus secretion, tears, bronchoconstriction, breathing difficulties, and other symptoms. The main adverse effects of capsaicin preparations are contact dermatitis, skin inflammation or blisters, and in severe situation burn-like lesion.Возможный контакт
Botanical animal and insect repellent used to repel birds, voles, deer, rabbits, squirrels, insects, and attacking dogs. Capsaicin, which is made from the Capsicum red chili pepper can be used indoors to protect carpets and upholstered furniture, and outdoors to protect fruit and vegetable crops, flowers, ornamental plants, shrubbery, trees, and lawns. It is also used in pepper sprays such as MACE, and as an analgesic in creams, lotions and solid sticks to reduce arthritic, postoperative and neuopathic pain, such as shingles. Capsaicin is obtained by grinding dried, ripe Capsicum frutescens L. chili peppers into a fine powder. The oleoresin is derived by distilling the powder in a solvent and evaporating the solvent. The resulting highly concentrated liquid has little odor but has an extremely pungent tasteПеревозки
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.Методы очистки
Recrystallise capcaicin from pet ether (b 40-60o), or pet ether/Et2O (9:1). Also purify it by chromatography on neutral Al2O3 (grade V) and elute successively with *C6H6, *C6H6/EtOAc (17:3) then *C6H6/EtOAc (7:3), and distil it at 120o/10-5mm, then repeatedly recrystallise the needles from isopropanol (charcoal). [Crombie et al. J Chem Soc 11025 1955, Bennett & Kirby J Chem Soc(C) 442 1968.] It causes pain and is neurotoxic [Bevan & Szolcsanyi Trends in Pharmacol Sci 11 330 1990, Beilstein 13 IV 2588].Несовместимости
Slowly hydrolyzes in water, releasing ammonia and forming acetate salts.Утилизация отходов
Do not discharge into drains or sewers. Dispose of waste material as hazardous waste using a licensed disposal contractor to an approved landfill. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Incineration with effluent gas scrubbing is recommended. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Noncombustible containers should be crushed and buried under more than 40 cm of soil. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA officeКапсаицин запасные части и сырье
Капсаицин поставщик
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