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Фурсультиамин
- английское имяFursultiamine
- CAS №804-30-8
- CBNumberCB1161096
- ФормулаC17H26N4O3S2
- мольный вес398.54
- EINECS212-357-1
- номер MDLMFCD00867383
- файл Mol804-30-8.mol
химическое свойство
Температура плавления | 130-136°C (decompos.) |
Температура кипения | 652.3±55.0 °C(Predicted) |
плотность | 1.29 |
показатель преломления | 1.6270 (estimate) |
температура хранения | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
растворимость | soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF). |
форма | Solid |
пка | 14.42±0.10(Predicted) |
цвет | White to Off-White |
Справочник по базе данных CAS | 804-30-8(CAS DataBase Reference) |
FDA UNII | 05J61265PX |
Словарь наркотиков NCI | fursultiamine |
Токсичность | LD50 in rats (mg/kg): 2200 orally; 540 i.p. (Yurugi, Fushimi) |
Фурсультиамин химические свойства, назначение, производство
Описание
Fursultiamine (syn. thiamine tetrahydrofurfuryl disulfide) is a vitamin B1 derivative which is rarely used, is only sparingly soluble in water and thus is usually employed only for solid drug forms. Lyophilisates are stabilized by sodium dextran sulfate.Химические свойства
white or slightly yellow crystalline powder. melting point 130-136 °C (decomposition). soluble in methanol, ethanol, chloroform, slightly soluble in acetone, insoluble in benzene, ether, slightly garlic odor.Использование
Fursultiamine is an oral source of thiamine, used in comparative pharmacokinectic analysis of thiamine and it’s phosphorylated metabolites administered as multivitamin preparations, identification of drug candidate against prostate cancer from aspect of somatic cell reprogramming, therapeutic tool in number of human neurological diseases.прикладной
Fursultiamine, a lipophilic vitamin B1 derivative, which is more readily absorbed in large amounts in the small intestine and has a longer half-life than its active counterpart vitamin B1. It is suitable for the treatment of beriberi or Wernicke encephalopathy due to vitamin B1 deficiency. It can also be used for the adjuvant treatment of peripheral neuritis and indigestion caused by vitamin B1 deficiency.Подготовка
Furanthiamine is obtained by condensing thiamine hydrochloride with sodium tetrahydrofuranmethyl thiosulfate after ring opening.Фурсультиамин запасные части и сырье
Фурсультиамин поставщик
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