Nitrofurazone
- русский язык имя
- английское имяNitrofurazone
- CAS №59-87-0
- CBNumberCB0492724
- ФормулаC6H6N4O4
- мольный вес198.14
- EINECS200-443-1
- номер MDLMFCD00003225
- файл Mol59-87-0.mol
химическое свойство
| Температура плавления | 242-244 °C (lit.) |
| Температура кипения | 335.43°C (rough estimate) |
| плотность | 1.6031 (rough estimate) |
| показатель преломления | 1.6500 (estimate) |
| Fp | 2 °C |
| температура хранения | 2-8°C |
| растворимость | Very slightly soluble in water, slightly soluble in ethanol (96 per cent). |
| пка | pKa 9.28± 0.03( EtOH,t =35±0.1,I=0.00) (Uncertain) |
| форма | Solid |
| цвет | Yellow to Dark Yellow |
| Растворимость в воде | <0.1 g/100 mL at 19 ºC |
| Чувствительный | Light Sensitive |
| Мерк | 14,6600 |
| БРН | 86403 |
| ИнЧИКей | IAIWVQXQOWNYOU-FPYGCLRLSA-N |
| Справочник по базе данных CAS | 59-87-0(CAS DataBase Reference) |
| FDA 21 CFR | 530.41 |
| Рейтинг продуктов питания EWG | 1 |
| FDA UNII | X8XI70B5Z6 |
| Предложение 65 Список | Nitrofurazone |
| Код УВД | B05CA03,D08AF01,D09AA03,P01CC02,S01AX04,S02AA02 |
| МАИР | 3 (Vol. 50) 1990 |
| Справочник по химии NIST | 5-Nitro furfural semicarbazone(59-87-0) |
| Система регистрации веществ EPA | Nitrofurazone (59-87-0) |
больше
| Коды опасности | Xn,F | |||||||||
| Заявления о рисках | 22-36-20/21/22-11 | |||||||||
| Заявления о безопасности | 36-36/37-26-16 | |||||||||
| РИДАДР | 3249 | |||||||||
| WGK Германия | 3 | |||||||||
| RTECS | LT7700000 | |||||||||
| F | 8 | |||||||||
| TSCA | Yes | |||||||||
| Класс опасности | 6.1(b) | |||||||||
| Группа упаковки | III | |||||||||
| кода HS | 29321900 | |||||||||
| Банк данных об опасных веществах | 59-87-0(Hazardous Substances Data) | |||||||||
| Токсичность | LD50 in rats (g/kg): 0.59 orally; 3.0 s.c. (Godwin) | |||||||||
| NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H302：Вредно при проглатывании.
H317：При контакте с кожей может вызывать аллергическую реакцию.
H341：Предполагается, что данное вещество вызывает генетические дефекты.
H351：Предполагается, что данное вещество вызывает раковые заболевания.
H373：Может поражать органы (Нервная система) в результате многократного или продолжительного воздействия при вдыхании.
H361fd：Предполагается, что данное вещество может отрицательно повлиять на способность к деторождению. Предполагается, что данное вещество может отрицательно повлиять на неродившегося ребенка.
H412：Вредно для водных организмов с долгосрочными последствиями.
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оператор предупредительных мер
P202：Перед использованием ознакомиться с инструкциями по технике безопасности.
P273：Избегать попадания в окружающую среду.
P280：Использовать перчатки/ средства защиты глаз/ лица.
P301+P312：ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P302+P352：ПРИ ПОПАДАНИИ НА КОЖУ: Промыть большим количеством воды.
P308+P313：ПРИ подозрении на возможность воздействия обратиться за медицинской помощью.
Nitrofurazone химические свойства, назначение, производство
Описание
Nitrofurazone is an antibacterial agent used in animal feed. Occupational dermatitis was reported in cattle breeders and farmers.Химические свойства
white to light yellow crystal powdeИспользование
Nitrofurazone is a topical anti-infective and bactericide for most pathogens commonly causing surface infections; in the adjunctive therapy of patients with second and third degree bums when bacterial resistance to other agents is areal or potential problem; in skin grafting where bacterial contamination may cause graft rejection and/or donor-site infection; antibacterial agent for the treatment or prevention of infections in a variety of conditions involving skin, eyes, ears, nose and genito-urinary tract; used on pyodermas, ulcers, and wounds; affects some protozoa and is an effective prophylaxis against nosocomial infections; antiseptic lubricant for trans urethral resection; anti-microbial in veterinary medicine.Показания
Nitrofurazone (Furacin), a synthetic nitrofuran derivative with a broad antibacterial spectrum. Although its exact mechanism of action is unknown, it is thought to inhibit bacterial enzymes involved in carbohydrate metabolism. It is not effective against fungal or viral organisms. It is used as adjunctive therapy in patients with second- and third-degree burns when bacterial resistance to other antiinfective agents is a potential problem. It is not effective in the treatment ofminor burns or superficial bacterial infections involving wounds, cutaneous ulcers, or various pyodermas. It is rarely used by dermatologists as it carries a high risk of acquired contact sensitivity.Определение
ChEBI: A semicarbazone resulting from the formal condensation of semicarbazide with 5-nitrofuraldehyde. A broad spectrum antibacterial drug, although with little activity against Pseudomonas species, it is used as a local application for burns, ulcer , wounds and skin infections.Всемирная организация здравоохранения(ВОЗ)
Nitrofural, a nitrofuran derivative with broad-spectrum antibacterial activity, was introduced in the early 1940s for the topical treatment of various skin conditions. It has also been used systemically for the treatment of African trypasonomiasis. Following recent findings of in vitro mutagenicity and of carcinogenicity in experimental animals, use of topical preparations containing this substance was restricted in Germany. Nitrofural remains registered in several countries and the World Health Organization is not aware of restrictive action having been taken elsewhere.Общее описание
Odorless pale yellow needles or yellow powder. pH (saturated aqueous solution) 6.0 - 6.5. Alkaline solutions are dark orange.Реакции воздуха и воды
Insoluble in water.Профиль реактивности
Furacilin darkens on prolonged exposure to light. Furacilin can react violently with reducing materials. .Пожароопасность
Flash point data for Furacilin are not available; however, Furacilin is probably combustible.Фармацевтические приложения
A synthetic compound used in the topical treatment of wounds and burns and as an instillation for bladder washout. A nitrofurazone-impregnated urinary catheter is said to reduce infection in catheterized patients. Activity against the common bacterial pathogens is sufficient to cover most pathogens that cause infections of burns and wounds, with the important exception of Ps. aeruginosa. Attention has been drawn to its activity against methicillin-resistant Staphylococcus aureus, and its use in clearing carriage has been suggested. Slight absorption occurs from intact skin (c. 1%) and burned skin (5%). It is neither a primary irritant nor a sensitizer, but some preparations contain polyethylene glycol as a vehicle, and absorption can cause problems in patients with reduced renal function. Of limited availability.Контактные аллергены
Nitrofurazone is an antibacterial agent used in animal feeds. Occupational dermatitis was reported in cattle breeders or farmers.Клиническое использование
5-Nitro-2-furaldehyde semicarbazone (Furacin) occurs asa lemon-yellow crystalline solid that is sparingly solublein water and practically insoluble in organic solvents.Nitrofurazone is chemically stable, but moderately lightsensitive.It is used topically in the treatment of burns, especiallywhen bacterial resistance to other agents may be a concern.It may also be used to prevent bacterial infection associatedwith skin grafts. Nitrofurazone has a broad spectrumof activity against Gram-positive and Gram-negative bacteria,but it is not active against fungi. It is bactericidalagainst most bacteria commonly causing surface infections,including S. aureus, Streptococcus spp., E. coli,Clostridium perfringens, Enterobacter (Aerobacter) aerogenes,and Proteus spp.; however, P. aeruginosa strainsare resistant.Nitrofurazone is marketed in solutions, ointments, andsuppositories in a usual concentration of 0.2%.Профиль безопасности
Poison by ingestion and intraperitoneal routes. Moderately toxic by subcutaneous route. Questionable carcinogen with experimental carcinogenic, neoplas tigenic, tumorigenic, and teratogenic data, Experimental reproductive effects. A human sensitizer. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.Nitrofurazone запасные части и сырье
Nitrofurazone поставщик
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