N,N-Dimethylformamide Dimethyl Acetal: Catalytic Role in Synthesis Reactions and its Toxicity

N,N-Dimethylformamide dimethyl acetal, also known as DMF-DMA or 1,1-dimethoxytrimethylamine, belongs to the class of organic compounds known as carboxylic acid amide acetals. It is the important intermediate of synthesizing heterocyclic compounds, Also be a kind of good methylating reagent and esterification dehydrant, particularly its as medicine synthetic intermediate, may be used for carbonamidine, The synthesis of the medicines such as 1,2,3-three ketones, indole, quinolones, ofloxacin, milrinone and allopurinol.

Toxicity

Based on a literature review very few articles have been published on N,N-Dimethylformamide dimethyl acetal. This compound has been identified in human blood as reported by (PMID: 31557052 ). N,N-dimethylformamide dimethyl acetal is not a naturally occurring metabolite and is only found in those individuals exposed to this compound or its derivatives. Technically N,N-Dimethylformamide dimethyl acetal is part of the human exposome. The exposome can be defined as the collection of all the exposures of an individual in a lifetime and how those exposures relate to health. An individual's exposure begins before birth and includes insults from environmental and occupational sources.

Catalytic Role in Synthesis Reactions

N,N-Dimethylformamide dimethyl acetal can be used as: 

An organocatalyst for the synthesis of 1,2-disubstituted-3,4-dihydronaphthalenes by the reaction of vinylarenes and electron-deficient alkynes.    

A building block for the preparation of heterocyclic compounds such as enamines and amidines via formylation of methylene and amino groups.     

A reagent in the synthesis of 1,4-diaryl-piperazine-2,5-diones by reacting with chloroacetamides.      

A reagent along with enamine and alkyne for the preparation of 2,3,4,5-tetrasubstituted pyridine derivatives by three-component coupling reaction in the presence of Me3SiCl.

You may like