Benefits of Spermidine

Spermidine is a low molecular weight aliphatic carbide containing three amine groups, and is one of the natural polyamines present in all living organisms. It is an important raw material for drug synthesis and is widely used in the synthesis of pharmaceutical intermediates.

Spermidine content was high in dry soy bean, chicken liver, green peas, corn, shell fish, and blue cheese. A high content of spermine was found in most of the meat products (like sausages, pork, chicken, and turkey), some vegetables (like pumpkin), and cheese.

Spermidine is crucial in the process of cell renewal. As old cells die, other cannibalise them and put molecules to use in building new cells. As we get older our natural levels of spermidine decrease reducing the ability of our cells to renew and repair themselves.In a 2016 study, spermidine was found to turn back the aging clock and improve cardiovascular function in aged mice. At the organ level, heart structure and function were improved in the aged mice given spermidine.

Spermidine has also been shown to reduce the risks of some forms of cancer, preserve telomere length and, if taken regularly enough over a long period of time, can expand lifespan. It also maintains autophagy in T cells and may improve vaccine protection in older adults. Research shows that spermidine inhibits five of the nine hallmarks of aging.

Spermidine plays a key role in maintaining cells’ membrane potential and controlling intracellular pH and volume.Studies also suggest it can reduce the risk of cardiovascular disease and improve cognition. Spermidine has a neuroprotective effect against neuron damage caused by inflammation and ischemia and oxidative stress.

Spermidine is a relatively new player on the scene, but is being increasingly used in supplement products. It is not a silver bullet, and will not offer a miracle extension of your life expectancy on you own. However, it does mimic some of the other life extending interventions such as calorie restriction in keeping cells healthier, improving brain function and keeping your body ticking over for a little bit longer.

There are currently no known side effects from the intake of spermidine. Countless trials and scientific studies have already been conducted on this subject and the results show the full tolerance of this natural ingredient by our body. Because spermidine is not only absorbed by our daily food, but our body itself produces spermidine. 

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