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2-Methyl-2-propanethiol

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2-Methyl-2-propanethiol Basic information
2-Methyl-2-propanethiol Chemical Properties
  • Melting point:-1.1 °C
  • Boiling point:62-65 °C(lit.)
  • Density 0.8 g/mL at 25 °C(lit.)
  • vapor density 3.1 (vs air)
  • vapor pressure 303.5 mm Hg ( 37.7 °C)
  • refractive index n20/D 1.423(lit.)
  • Flash point:−12 °F
  • storage temp. Flammables area
  • solubility 1.47g/l slightly soluble
  • pkapK1:11.22 (25°C,μ=0.1)
  • form Liquid
  • color Clear colorless
  • Odor Threshold0.000029ppm
  • Water Solubility Slightly soluble in water
  • Merck 14,1579
  • BRN 505947
  • Stability:Stable. Flammable - note low flashpoint. Incompatible with strong oxidizing agents.
  • CAS DataBase Reference75-66-1(CAS DataBase Reference)
  • NIST Chemistry Reference2-Propanethiol, 2-methyl-(75-66-1)
  • EPA Substance Registry System2-Propanethiol, 2-methyl- (75-66-1)
Safety Information
MSDS
2-Methyl-2-propanethiol Usage And Synthesis
  • Descriptiontert-Butylthiol, also known as 2-methyl propane-2-thiol, 2- methyl-2-propane thiol, tert-butyl mercaptan (TBM), and t-BuSH, is an organo sulfur compound with the formula (CH3)3CSH. This thiol may have been used as a flavoring agent, as an odorant for natural gas (which is odorless), and also in a wide range of organic reactions.
  • Chemical Propertiesliquid with an exceedingly unpleasant smell
  • Uses2-Methyl-2-propanethiol was used in reaction of 2-methyl-2-propanethiol on Mo(110) using temperature programmed reaction, high resolution electron enegy loss and X-ray photoelectron spectroscopies. It was used in the synthesis of chain-transfer agents for reversible addition-fragmentation chain-transfer copolymerization of vinylidene chloride and methyl acrylate.
  • UsesTert-Butylthiol is the main ingredient in many gas odorant blends. It is always utilized as a blend of other compounds, typically dimethyl sulfide, methyl ethyl sulfide, tetrahydrothiophene or other mercaptans (isopropyl mercaptan, sec-butyl mercaptan and/or n-butyl mercaptan, due to its rather high melting point of 273 K. These blends are used only with natural gas and not propane, as the boiling points of these blends and propane are quite different. As propane is delivered as a liquid and vaporizes to gas when being delivered to the appliance, the vapor liquid equilibrium would substantially reduce the amount of odorant blend in the vapor.
    Tert - Butyl thiol has been listed on the European Food Safety Authority (FL-no: 12.174) as a flavor additive. There is no indication of what flavor or flavors it may have been used in. It has been removed from this list.
  • Preparationtert-Butyl thiol likely does not occur naturally, but at least one publication has listed it as a very minor component of cooked potatoes. The compound was first prepared in 1890 by Leonard Dobbin by the reaction of zinc sulfide and t-butyl chloride.
    The compound was later prepared in 1932 by the reaction of the Grignard reagent, t-BuMgCl, with sulfur to give the corresponding thiolate, followed by hydrolysis. This preparation is shown below:
    t-BuMgCl + S → t-BuSMgCl
    t-BuSMgCl + H2O → t-BuSH + Mg(OH)Cl
    It is currently prepared industrially by the reaction of isobutylene with hydrogen sulfide over a clay (silica alumina) catalyst.
  • Reactionstert-Butylthiol can react with metal alkoxides and acyl chlorides to form thiol esters, as shown in the equation :
    In the reaction above, thallium (I) ethoxide converts to thallium (I) t-butyl thiolate. In the presence of diethyl ether, thallium (I) tbutylthiolate reacts with acyl chlorides to give the corresponding tertbutyl thioesters. Like other thio esters, it reverts back to tert-butylthiol by hydrolysis.
    Lithium 2-methyl propane-2-thiolate can be prepared by treatment of tert-butyl thiol with lithium hydride in an aprotic solvent such as hexa methyl phosphorous triamide (HMPT). The resulting thiolate salt is a useful demethylating reagent. For example, treatment with 7- methyl guanosine gives guanosine. Other N-methylated nucleosides in tRNA are not demethylated by this reagent .
  • HazardFlammable, dangerous fire risk. Very toxic.
  • Safety ProfileModerately toxic by intraperitoneal route. Mildly toxic by ingestion. An eye irritant. A very dangerous fire hazard when exposed to heat or flame. Can react vigorously with oxidizing materials. To fight fire, use alcohol foam, dry chemical, mist, fog. When heated to decomposition or on contact with acid or acid fumes it emits highly toxic fumes of SOx.
  • SafetyEven in well ventilated areas, extreme caution must be made when handling tert-butylthiol as it is a highly odorous chemical with an odor threshold of < 0.33 ppb. Extreme caution is not due to toxicity, but due to the significant odor and concerns that this odor would cause to the many individuals that might be exposed. The PEL for thiols of most types is 500 ppb, primarily due to reaction of nausea at levels of 2–3 ppm. The LC50 of tert-butylthiol is much, much higher.
  • Purification MethodsDry the thiol for several days over CaO, then distil it from CaO. Purify it as for 2-methylpropane-1-thiol above. [Beilstein 1 H 383, 1 II 416, 1 III 1589, 1 IV 1634.]
  • Metal complexesThe anion derived from tert – butyl thiol forms complexes with various metals. One example is tetra kis (tert-butyl thiolato ) molybdenum (IV), Mo(t-BuS)4. This complex was prepared by treating MoCl4 with t-BuSLi :
    Mo Cl4 + 4t-Bu S Li → Mo (t-BuS)4 + 4LiCl
    Mo(t-BuS)4 is a dark red diamagnetic complex that is sensitive to air and moisture. The molybdenum center has a distorted tetra hedral coordination to four sulfur atoms, with overall D2 symmetry.
2-Methyl-2-propanethiol Preparation Products And Raw materials
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