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4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline

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4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Basic information
4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Chemical Properties
  • Boiling point:329.1±42.0 °C(Predicted)
  • Density 1.227
  • storage temp. Keep in dark place,Inert atmosphere,2-8°C
  • pka7.55±0.10(Predicted)
4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Usage And Synthesis
  • Uses4-(6-Acryloyloxyhexyloxy)-benzoesure (4-cyanophenylester) can be used as an intermediate in organic synthesis, mainly used in laboratory research and development and in the process of chemical and pharmaceutical synthesis.
  • Chemical Synthesis
    4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline Into a solution 4-methyl-1-(4-nitro-2-(trifluoromethyl)benzyl)piperazine (1.5 g, 5 mmol) in MeOH (250 mL) was added Raney Nickel (0.15 g, 10 wt %). The suspension was stirred under hydrogen atmosphere (50 psi) for 24 hrs and monitored by TLC. The reaction mixture was filtered through celite and the filtrate was concentrated under reduced pressure to yield the desired product (1.36 g, 100%). 1H NMR (300 MHz, CDCl3) δ: 7.43-7.46 (1H, d, J=9.0 Hz), 6.91 (1H, s), 6.77-6.80 (1H, d J=9.0 Hz), 3.77 (2H, s), 3.54 (2H, s), 2.53 (8H, brs), 2.34 (3H, s).
4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline(694499-26-8)Related Product Information
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