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Galeterone

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Galeterone Basic information
Galeterone Chemical Properties
  • Melting point:189-190℃
  • Boiling point:564.5±60.0 °C(Predicted)
  • Density 1.28
  • pka14.71±0.70(Predicted)
Galeterone Usage And Synthesis
  • DescriptionThe cytochrome P450 (CYP) isoform CYP17 is also known as steroid 17α-hydroxylase/17,20 lyase because it catalyzes both 17α-hydroxylase and 17,20 lyase reactions in the synthesis of steroids, including androgens, estrogens, glucocorticoids, and mineralocorticoids. Galeterone is a CYP17 inhibitor (IC50 = 300 nM) that has been shown to competitively block synthetic androgen binding (EC50 = 845 nM) and to antagonize the androgen receptor in transcriptional activation assays. Galeterone can inhibit the growth of castration-resistant prostate cancer cells with an IC50 value of 2.9 μM and demonstrates synergy with everolimus (Item No. 11597) or gefitinib (Item No. 13166) for growth inhibition.
  • UsesGaleterone is an androgen receptor antagonist and CYP17A1 enzyme inhibitor.
Galeterone(851983-85-2)Related Product Information
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  • Company Name:Shanghai Boyle Chemical Co., Ltd.
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