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Cefmetazole

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Cefmetazole Basic information
Cefmetazole Chemical Properties
  • Melting point:163-165?C
  • Density 1.4380 (rough estimate)
  • refractive index 1.7400 (estimate)
  • storage temp. 2-8°C
  • pka2.65±0.50(Predicted)
  • Water Solubility Soluble in water
  • CAS DataBase Reference56796-20-4(CAS DataBase Reference)
Safety Information
  • Hazard Codes Xn
  • Risk Statements 36/37/38-42/43
  • Safety Statements 26-36
  • WGK Germany 2
  • RTECS XI0372200
  • HS Code 2941906000
MSDS
Cefmetazole Usage And Synthesis
  • DescriptionCefmetazole is a cephamycin with a nonaromatic side chain at C-7. In addition to a fairly characteristic second-generation cephalosporin antimicrobial spectrum, it possess fairly significant anti-antiaerobic activity. The ejection of its C-3 side chain leads to alcohol intolerance of the disulfuram type and prolonged clotting times.
  • Chemical PropertiesWhite Solid
  • UsesSemi-synthetic antibiotic derived from Cephamycin. Antibacterial.
  • DefinitionChEBI: A cephalosporin antibiotic containg an N1-methyltetrazol-5-ylthiomethyl side-chain at C-3 of the parent cephem bicyclic structure.
  • Antimicrobial activityIt is active against Pr. mirabilis, Pr. vulgaris, Morganella morganii, Yersinia spp.and most anaerobes. S. marcescens is moderately susceptible, but Ps. aeruginosa and E. faecalis are resistant. It is active against Mycobacterium fortuitum and some strains of M. chelonei. It is resistant to a wide range of β-lactamases.
    The serum concentration at the end of a 1 g intravenous infusion is around 77 mg/L. Plasma protein binding is 68%. It is principally excreted in the urine with a plasma half-life of c. 1.3 h; 70% is recovered over the first 6 h. In patients whose creatinine clearance is less than 10 mL/min, plasma levels are elevated and the plasma half-life is increased to around 15 h.
    Side effects associated with the methylthiotetrazole group at position C-3 have been reported. Uses are similar to those of cefoxitin, but it is not widely available.
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