ChemicalBook Product Catalog Biochemical Engineering Plant extracts Sodium danshensu

Sodium danshensu

Product NameSodium danshensu
CAS67920-52-9
MFC9H11NaO5
MW222.17
EINECS804-287-0
MOL File67920-52-9.mol

Chemical Properties

storage temp.	Inert atmosphere,2-8°C
solubility	H2O : 100 mg/mL (454.24 mM; Need ultrasonic)DMSO : 100 mg/mL (454.24 mM; Need ultrasonic)
form	powder
color	White-beige
InChI	InChI=1S/C9H10O5.Na.H/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14;;/h1-3,8,10-12H,4H2,(H,13,14);;
InChIKey	UPKQTJGQYNOELB-UHFFFAOYSA-N
SMILES	C(C1C=CC(O)=C(O)C=1)C(O)C(=O)O.[NaH]

Safety Information

Hazard Codes	Xn
Risk Statements	22
Safety Statements	24/25
WGK Germany	WGK 3
HS Code	29329990
Storage Class	11 - Combustible Solids

Usage And Synthesis

Description

Danshensu is a salvianolic acid and the major component of S. miltiorrhiza (Danshen) and has diverse biological activities. It reduces expression of the autophagy-associated proteins p62, LC3-II, and Beclin-1 and the apoptosis-related proteins Bax and caspase-3, prevents cardiomyocyte damage, and increases heart rate, coronary flow (CF), and left ventricular developed pressure (LVDP) in an isolated rat heart model of ischemia and reperfusion injury. Danshensu (60 mg/kg per day) reduces infarct size and improves left ventricular function in a rat model of myocardial infarction. It enhances radiation-induced tumor cell death in a Lewis lung carcinoma mouse xenograft model. Danshensu also decreases infarct volume, neuronal apoptosis, production of TNF-α, IL-1β, and IL-6, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity in a rat model of cerebral ischemia and reperfusion injury.

Chemical Properties

White to light brown powder

Uses

Sodium Danshensu is exhibits protective effects on the excitotoxicity of monosodium glutamate in the late stage of pregnancy on developing mouse fetal brain.

in vivo

Salvianic acid A (3 or 10 mg/kg, p.o., once daily for 6 weeks) suppresses inflammatory reactions and inhibits oxidative stress in atherosclerosis (AS) rats induced by a high-fat diet, showing protective effects against atherosclerosis^[5].

Animal Model:	Atherosclerosis (AS) model induced by a high-fat diet in Sprague-Dawley rats (180-220 g)^[4]
Dosage:	3 or 10 mg/kg
Administration:	Oral gavage (p.o.), once daily for 6 weeks
Result:	Inhibited atherosclerotic lesion progression and reduced aortic lipid deposition by 58.2% and 72.8% in high-fat diet-induced AS rats. Improved lipid profiles by lowering triglyceri/brdes, total cholesterol, and LDL cholesterol while significantly increasing HDL cholesterol in AS rats. Enhanced antioxidant enzyme activity, upregulated the Nrf2/HO-1 pathway, and reduced the expression of p47phox and p22phox.

target

Calcium Channel | Potassium Channel | Akt | GSK-3 | Bcl-2/Bax | PI3K

References

[1] GUANWEI FAN. Danshensu alleviates cardiac ischaemia/reperfusion injury by inhibiting autophagy and apoptosis via activation of mTOR signalling[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2016, 20 10: 1908-1919. DOI: 10.1111/jcmm.12883
[2] YING YIN . Danshensu accelerates angiogenesis after myocardial infarction in rats and promotes the functions of endothelial progenitor cells through SDF-1α/CXCR4 axis[J]. European journal of pharmacology, 2017, 814: Pages 274-282. DOI: 10.1016/j.ejphar.2017.08.035
[3] HONG-YING CAO. Danshensu, a major water-soluble component of Salvia miltiorrhiza, enhances the radioresponse for Lewis Lung Carcinoma xenografts in mice.[J]. Oncology Letters, 2017, 13 2: 605-612. DOI: 10.3892/ol.2016.5508
[4] HANG XU. Synergistic neuroprotective effects of Danshensu and hydroxysafflor yellow A on cerebral ischemia-reperfusion injury in rats.[J]. Oncotarget, 2017, 8 70: 115434-115443. DOI: 10.18632/oncotarget.23272

Sodium danshensu Supplier

Sodium danshensu manufacturers

Related Product Information

Send Inquriy