| Name | Danshensu sodium salt |
| Description | Danshensu sodium salt (Sodium Danshensu) is sodium salt of danshensu from the widely used Chinese herb Danshen. It can inhibited phenylephrine- and CaCl2-induced vasoconstriction in Ca2+-free medium. |
| In vitro | The compound Sodium Danshensu was administered in two different methods to assess its toxicity. When orally administered to mice, the LD50 was determined to be 2356.33 mg/kg; conversely, when injected intravenously into rats, the LD50 was found to exceed 1500 mg/kg. |
| In vivo | Danshensu is an effective free radical scavenger and antioxidant. Sodium danshensu exerts a biphasic action on vascular tension, where a low dose may induce minor contractions through a momentary increase in Ca2+ influx, while higher doses predominantly cause significant vasodilation by facilitating the opening of non-selective K+ channels and small-conductance Ca2+-sensitive K+ channels in vascular smooth muscle cells. Additionally, sodium danshensu inhibits vasoconstriction induced by norepinephrine and CaCl2 in a free Ca(2+) medium. Pre-treatment with sodium danshensu can suppress vasoconstriction triggered by norepinephrine and KCl in a dose-dependent manner. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 2 mg/mL (9.08 mM)
DMSO : 50 mg/mL (227.11 mM), Heating is recommended.
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | Autophagy | Danshensu sodium salt | DanShenSu sodium sal | Danshensu | inhibit | Inhibitor | Danshensu sodium |
| Inhibitors Related | Stavudine | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Curcumin | Paeonol | Naringin | Gefitinib |
| Related Compound Libraries | Polyphenolic Natural Product Library | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Chinese Pharmacopoeia Natural Product Library | Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
United States
