White crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Salvia miltiorrhiza.
Danshensu increases production of collagenin Detroit 551 cells and attenuates the α-MSH-stimulated melanin production of B16 cells. Danshensu may be used as active ingredients in would healing, cosmetic treatments or treating hyperpigmentation.
ChEBI: (2R)-3-(3,4-dihydroxyphenyl)lactic acid is a (2R)-2-hydroxy monocarboxylic acid that is (R)-lactic acid substituted at position 3 by a 3,4-dihydroxyphenyl group. It is a (2R)-2-hydroxy monocarboxylic acid and a 3-(3,4-dihydroxyphenyl)lactic acid. It is a conjugate acid of a (2R)-3-(3,4-dihydroxyphenyl)lactate.
Danshensu (Dan shen suan A; 25, 50, 100mg/kg; oral administration daily for 7 continuous days or i.v. once) before SARS-CoV-2 S infection dose-dependently alleviates the pathological alterations in mice infected with SARS-CoV-2 S[1].
| Animal Model: | Adult BALB/c mice (male, 6-8 weeks, 20±2g)[1] |
| Dosage: | 25, 50, 100mg/kg |
| Administration: | Oral administration (daily for 7 continuous days) or i.v. (once) |
| Result: | Could prevent SARS-CoV-2 S protein-induced acute lung inflammation.
Ameliorated inflammatory cytokines in serum and lung tissue.
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