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Costunolide Basic information
Costunolide Chemical Properties
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 26-24/25
  • WGK Germany 3
  • HS Code 29322090
Costunolide Usage And Synthesis
  • Chemical PropertiesWhite powder
  • UsesA sequiterpene lactone that inhibits telomerase
  • DefinitionChEBI: A germacranolide with anthelminthic, antiparasitic and antiviral activities.
  • Biological ActivityInhibitor of human telomerase activity (IC 50 = 65 μ M in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines. Selectively blocks endothelial cell proliferation induced by VEGF. Inhibits expression of iNOS and IL-1 β and disrupts NF- κ B activation. Displays anti-inflammatory, antifungal and antiviral properties.
  • Contact allergensThis germacranolide sesquiterpene lactone is extracted from costus oil. With alantolactone and dehydrocostunolide, it is a component of lactone mix used to elicit reactions in patients sensitive to Asteraceae-Compositae. An erythema-multiform-like occupational contact dermatitis case occurred in a chemical student after an accidental exposure to costus oil.
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