magnessium lithospermate B

Product Namemagnessium lithospermate B
CAS122021-74-3
MFC36H28MgO16
MW740.9
EINECS
MOL File122021-74-3.mol

Chemical Properties

solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Powder
color	Light yellow to light brown
Cosmetics Ingredients Functions	SKIN PROTECTING ANTIMICROBIAL ANTIOXIDANT HUMECTANT HAIR CONDITIONING
InChIKey	ANUBYMNVOPVATP-OAZHBLANSA-L

Usage And Synthesis

Uses

Magnesium Lithospermate B, is a derivative of caffeic acid tetramer and an inhibitor of Na+/K+ ATPase, which can be extracted from Salviae miltiorrhizae. Magnesium Lithospermate B is widely used for the research of cardiovascular diseases, and it can protect against glucose-induced intracellular oxidative damage. Magnesium Lithospermate B also suppresses neuroinammation and attenuates neurodegeneration[1][2][3].

in vivo

Magnesium Lithospermate B (2-8 mg/kg; p.o. once daily for 16 d) reduces the renal damage of oxidative stress through reduction of reactive oxygen species in old rats^[1].
Magnesium Lithospermate B (0.5 μg/g; s.c. for 6 weeks) promotes the neurogenesis and improves the memory in PD models^[3].

Animal Model:	Young (5-month-old) and old (20-month-old) specific-pathogen-free male Sprague-Dawley rats^[1]
Dosage:	2, 8 mg/kg
Administration:	P.o. once daily for 16 days
Result:	Reduced the protein expression of major subunits of nicotinamide adenine dinucleotide phosphate oxidase (Nox4 and p22phox), phospho-p38, nuclear factor-kappa B p65, cyclooxygenase-2, and inducible nitric oxide synthase. Showed lower levels of senescence-related proteins such as p16, ADP-ribosylation factor 6, p53, and p21.

target

p65 | NF-kB | TGF-β/Smad | ROS | PDGFR

References

[1] Magnesium lithospermate B possesses inhibitory activity on Na+,K+‐ATPase and neuroprotective effects against ischemic stroke
[2] Park CH, et, al. Magnesium Lithospermate B from Salvia miltiorrhiza Bunge Ameliorates Aging-Induced Renal Inflammation and Senescence via NADPH Oxidase-Mediated Reactive Oxygen Generation. Phytother Res. 2017 May;31(5):721-728. DOI:10.1002/ptr.5789
[3] Quan W, et, al. Antioxidant properties of magnesium lithospermate B contribute to the cardioprotection against myocardial ischemia/reperfusion injury in vivo and in vitro. J Tradit Chin Med. 2013 Feb; 33(1): 85-91. DOI:10.1016/s0254-6272(13)60106-5
[4] Zhang Z, et, al. Magnesium lithospermate B promotes proliferation and differentiation of neural stem cells in vitro and enhances neurogenesis in vivo. Tissue Cell. 2018 Aug; 53:8-14. DOI:10.1016/j.tice.2018.05.012

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