Iamin gel was launched in the US for the care of chronic and acute wounds.
It can be prepared by combining the tripeptide GHK and copper (Ⅱ) acetate. There
are several species present in equilibrium but the biscomplex is the dominant
compound at neutral pH. The GHK sequence is found in only eight human proteins
and is an endogenous growth factor that stimulates collagen synthesis and
angiogenesis. This is part of the explanation for its wound healing and tissue repair
ability. It can significantly delay fibroblast activation, is a growth factor for
hepatocyctes, neurons, thyroid follicular cells and is a chemoattractant for
monocytes, macrophages, mast cells and capillary endothelial cells. Copper is also
known to have an effect on lysyl oxidase which is a key enzyme involved in collagen
formation.
Prezatide is used for skin care, and has the potential to treat chronic obstructive pulmonary disease and metastatic colon cancer. Prezatide copper acetate is used in personal skin care products with anti-inflammatory and anti-allergic effects, such as essence lotion, cream, facial mask and sunscreen, etc
