Dipeptide-2 is a tiny peptide with only two amino acids (amino acids are the building block of proteins, and peptides are a few amino acids attached together), Valine and Tryptophan. It's part of a 3 actives complex called Eyeliss (with HMC and Palmitoyl Tetrapeptide-7) that's supposed to fight under-eye bags.
The manufacturer claims that this dipeptide in Eyeliss can increase lymphatic circulation and the three actives together represent a "global approach to treating puffy eyes". The clinical study of the manufacturer with 20 people and 3% Eyeliss showed improvement after 56 days for 70% of the participants.
H-VAL-TRP-OH is a white or off-white lyophilized powder.
Dipeptide 2 (N-Valyltryptophan; Val-Trp) is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient[1]. Dipeptide 2 is an angiotensin-converting Enzyme (ACE)[2].
ChEBI: Dipeptide-2 is a synthetic peptide used for skin care.
Dipeptide-2 is a potent angiotensin-converting enzyme (ACE) inhibitor, which reduces vasoconstriction of blood vessels around the eyes by inhibiting ACE activity and promotes blood circulation, thus improving periorbital edema and reducing dark circles.
[1] Zhang L, et al. Cosmeceuticals and peptides. Clin Dermatol. 2009;27(5):485-494. DOI:
10.1016/j.clindermatol.2009.05.013[2] Bicak B. Structural, spectroscopic, molecular docking, ADME, molecular dynamics studies of Val-Trp dipeptide. J Biomol Struct Dyn. 2023;41(23):13873-13890. DOI:
10.1080/07391102.2023.2183041
