MET-GLU-HIS-PHE-ARG-TRP-GLY

Product NameMET-GLU-HIS-PHE-ARG-TRP-GLY
CAS4037-01-8
MFC44H59N13O10S
MW962.09
EINECS
MOL File4037-01-8.mol

Chemical Properties

Density	1.48±0.1 g/cm3(Predicted)
RTECS	MC0596950
storage temp.	−20°C
form	Solid
pka	3.32±0.10(Predicted)
color	White to off-white
Sequence	Met-Glu-His-Phe-Arg-Trp-Gly

Safety Information

WGK Germany

MSDS

Provider	Language
SigmaAldrich	English

Usage And Synthesis

Uses

Adrenocorticotropic Hormone (ACTH) (4-10), human is a melanocortin 4 (MC4R) receptor agonist.

Biological Activity

Adrenocorticotropic Hormone (ACTH) (1-39), rat is a potent melanocortin 4 receptor (MC4R) agonist.

in vitro

Adrenocorticotropic Hormone (ACTH) (4-10), human (ACTH (4-10)) is the core sequence of all melanocortins and binds selectively to MC4-R. In humans, ACTH (4-10) enters the cerebral fluid compartment after intranasal application and leads to a decrease in total body fat after 6 weeks of continuous treatment.

target

Melanocortin 4 receptor

IC 50

MC4R

References

[1] Wellh?ner P, et al. Intranasal application of the melanocortin 4 receptor agonist MSH/ACTH(4-10) in humans causes lipolysis in white adipose tissue. Int J Obes (Lond). 2012 May;36(5):703-8. DOI:10.1038/ijo.2011.105