Palmitoyl tetrapeptide-7 is derived from dehydroepiandosterone, a steroid normally synthesized and
released from the adrenal gland. DHEA has been shown to reduce inflammation, support wound healing,
and slow down the skin aging process. The ability of palmitoyl tetrapeptide-7 downregulates IL-6 and other proinflammatory cytokines has been shown to be comparable to anti-inflammatory properties of
DHEA in vitro in both resting cells and cells stressed with inflammation. Rigin, a cream containing
Palmitoyl tetrapeptide-7, has been shown to improve skin elasticity and texture.
Rigin is a tuftsin-like tetrapeptide with the sequence G-Q-P-R that is derived from IgG. Rigin exhibits immunomodulatory activity, stimulating phagocytosis, activating polymorphonuclear lymphocytes and macrophages, and protecting against stress-induced damage.