PJ34
PJ34 性质
| 储存条件 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
|---|---|
| 溶解度 | H2O：可溶，22mg/mL |
| 形态 | 白色固体 |
| 颜色 | 白色至黄色 |
| 水溶解性 | water: 5mg/mL |
| 敏感性 | Light Sensitive & Hygroscopic |
| 稳定性 | 从购买之日起 2 年内保持稳定。 DMSO 或蒸馏水中的溶液可在 -20℃ 下储存长达 3 个月。 |
| InChI | 1S/C17H17N3O2.ClH.H2O/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15;;/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22);1H;1H2 |
| InChIKey | YCALIZUKAFUQCH-UHFFFAOYSA-N |
| SMILES | Cl[H].[H]O[H].CN(C)CC(=O)Nc1ccc2NC(=O)c3ccccc3-c2c1 |
PJ34 用途与合成方法
|
PARP 110 nM (IC 50 ) |
PARP-2 86 nM (IC 50 ) |
PARP-1 110 nM (IC 50 ) |
PJ34 inhibits the PARP enzyme activity with an IC 50 of 110±1.9 nM. To compare the neuroprotective properties of other PARP inhibitors in PC12 cells, PJ34 is evaluated using by LDH assay. PJ34 treatment also significantly and concentration dependently attenuates cell death at a concentration ranging from 10 -7 to 10 -5 M.
To compare the potency and efficacy with other PARP inhibitors, PJ34 is evaluated at the doses of 3.2 and 10 mg/kg, respectively. PJ34 at the dose of 3.2 mg/kg significantly reduces cortical damage by 33%; however, 10 mg/kg dosing shows reversed effect (17% reduction). PJ34 (25 mg/kg) reduces the levels of TNF-α mRNA in ischemic animals by 70% and these values in treated mice do not differ from that of sham or naive animals. Treatment of ischemic mice with PJ34 reduces the level of E-selectin mRNA by 81% and that of ICAM-1 mRNA by 54%, compared to vehicle-treated ischemic mice.
PJ34 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-13688 | 344458-15-7 | 5 mg | 347 | |
| 2026-09-15 | HY-13688 | PJ34 | 344458-15-7 | 10 mM * 1 mLin DMSO | 381 |
