White to off-white powder
1-Hydroxybenzotriazole hydrate can be used as a condensation reagent to prepare:
- Poly-γ-glutamic acid methyl ester from a dimer of γ-glutamic acid.
- Oxadiazoles via cyclo condensation of amidoximes with trifluoroacetic anhydride or benzoic acid derivatives.
A common additive for peptide coupling.
additive for oligonucleotide couplings and in racemization-free peptide couplings
1-Hydroxybenzotriazole is a coupling reagent used to synthesize amides by the condensation reaction between the activated ester/acid and the amino group of protected amino acids. It is also used as a racemization suppressor during peptide synthesis.
reaction type: Addition Reactions
The ITSL 1-Hydroxy benzotriazole has been changed from 0.04 μg/m3 to 0.1 μg/m3
based on an annual averaging time.
