3-Bromo-1-chloro-4-fluorobenzene is an organic intermediate that can be prepared from p-fluoronitrobenzene via a three-step reaction. Literature reports that it can be used to prepare 5-chloro-2-methoxybenzonitrile, which is mainly used in the pharmaceutical and pesticide industries.
3-Bromo-1-chloro-4-fluorobenzene is an organic intermediate prepared from p-fluoronitrobenzene through a three-step reaction. Literature reports that it can be used to prepare 5-chloro-2-methoxybenzonitrile, which is mainly used in the pharmaceutical and pesticide industries.
Colorless to light yellow liquid
(1) Bromination: p-Fluoronitrobenzene reacts with N-bromosuccinimide in acetic acid at 15C to yield 3-bromo-4-fluoronitrobenzene.
(2) Reduction: 3-Bromo-4-fluoronitrobenzene is reduced with iron powder/ammonium chloride to give 3-bromo-4-fluoroaniline.
(3) Diazotization-Sandmeyer: 3-Bromo-4-fluoroaniline is diazotized and then reacted with cuprous chloride to yield 3-bromo-1-chloro-4-fluorobenzene.
