4-(4-Methylpiperazino)aniline

16155-03-6

16153-81-4

GENERAL METHOD: 1-methyl-4-(4-nitrophenyl)piperazine (5.53 mmol) was dissolved in methanol (15 mL) and stirred under N2 atmosphere. Pd/C (2.78 mmol) was added to this solution. Subsequently, the reaction flask was placed in H2 atmosphere (balloon) for hydrogenation reaction overnight. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth plate and the filtrate was concentrated under vacuum. The crude product was purified by silica gel column chromatography (eluent: 5% MeOH/DCM containing 1% NH3) to afford the target compound 4-(4-methyl-1-piperazinyl)aniline (3a) as a brown solid in 87% yield.