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Aristolochic acid

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Aristolochic acid Basic information
Aristolochic acid Chemical Properties
  • Melting point:260 °C
  • Boiling point:476.92°C (rough estimate)
  • Density 1.3162 (rough estimate)
  • refractive index 1.4500 (estimate)
  • storage temp. 2-8°C
  • solubility DMSO: soluble
  • form powder
  • pka2.99±0.20(Predicted)
  • color yellow
  • InChIKeyLIDQMWRBMLSXLL-UHFFFAOYSA-N
  • CAS DataBase Reference313-67-7(CAS DataBase Reference)
  • IARC1 (Vol. 82, 100A) 2012, 1 (Vol. 82, 100A) 2012
Safety Information
  • Hazard Codes T
  • Risk Statements 25-68-36/37/38-23/24/25-45
  • Safety Statements 7-35-45-36/37/39-26-53
  • RIDADR UN 1544 6.1/PG 3
  • WGK Germany 3
  • RTECS CF3325000
  • HazardClass 6.1(b)
  • PackingGroup III
  • HS Code 29329990
  • ToxicityLD50 in male, female mice, male, female rats (mg/kg): 38.4, 70.1, 82.5, 74.0 i.v.; 55.9, 106.1, 203.4, 183.9 orally (Mengs)
MSDS
Aristolochic acid Usage And Synthesis
  • Chemical PropertiesShiny brown leaflets or a yellow or white powder.
  • UsesPLA2 inhibitor
  • UsesAristolochic acids occur in Aristolochiaceae and in butterflies feeding on these plants. One of a group of fourteen known, substituted 1-phenanthrenecarboxylic acids
  • DefinitionChEBI: A monocarboxylic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is b th carcinogenic and nephrotoxic.
  • brand nameAcidum aristolchicum;Descresepet;Fago-araxin;Fluocinova;Predno-facilus haemota.
  • World Health Organization (WHO)Extracts of aristolochiaceae have traditionally been used as a bitter for which a broad range of therapeutic effects has been claimed. Aristolochic acid is claimed to promote phagocytosis and to have immunostimulant activity. However, in 1981, a three-month toxicity study in rats revealed the carcinogenic potential of aristolochic acid and preparations containing this substance have since been withdrawn in several countries.
  • Safety ProfileConfirmed carcinogen. Poison by ingestion, intraperitoneal, and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NO,. Potentially Toxic Chemicals: April 1982." Vol. 5 No. 1: The Ministry of Health of the Federal Republic of Germany has withdrawn from the national market drugs containing aristolochic acid. The decision resulted from the demonstration of a carcinogenic potential in a three-month ingestion toxicity study undertaken in rats. Aristolochic acid is claimed to promote phagocytosis and to have immunostimulant activity. A growth-inhibiting effect on experimentally induced tumors has been described, but this effect has not been shown to have any clinical relevance. Extracts of species of Aristolochiacea have tradtionally been used as a bitter, and a broad range of therapeutic effects has been claimed.
  • Potential ExposureAristolochic acids are alkaloids used primarily as a chemical intermediate for pharmaceuticals, lab chemicals, herbal extract, drug.
  • ShippingUN1544 Alkaloids, solid, n.o.s. or Alkaloid salts, solid, n.o.s. poisonous, Hazard Class: 6.1; Labels: 6.1- Poisonous materials, Technical Name Required. PG III.
  • IncompatibilitiesCompounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
  • Waste DisposalIt is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. All federal, state, and local environmental regulations must be observed.
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