The existing preparation method usually employs acylase to cleave 7-phenylacetamidocephalosporanic acid, and then obtains 7-ADCA by acidification, dichloromethane extraction to remove impurities, activated charcoal decolorization and crystallization, etc. However, in this process, after obtaining the cleavage solution, the steps of removing impurities and decoloration are more cumbersome, and after decoloration with activated charcoal, in the subsequent reaction process, some of the substances come into contact with oxygen in the air, and are prone to appear color again, and the effect of removing impurities and decolorization is poor.
