1,8-Diamino-3,6-dioxaoctane

Amino-PEG2-Amine is a crosslinker containing two amino groups. The hydrophilic PEG spacer increases solubility in aqueous media. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

CLEAR COLOURLESS LIQUID

2,2'-(Ethylenedioxy)bis(ethylamine) is used to linker to form conjugates of manganese-doped zinc sulfide nanoparticles with folic acid.

1,8-Diamino-3,6-dioxaoctane is a chelating agent that has been shown to have antibacterial efficacy against gram-positive bacteria. It has been demonstrated to bind to a variety of functionalities such as amines, low energy metals, and hydroxy groups. It has been studied in the synthesis of coordination complexes with a range of geometric structures. The synthesis methods for this compound include solid-phase synthesis and hydrolysis of ethylenediamine. This compound has also been used as an electron donor in fluorescence techniques and morphology studies.

ChEBI: Ethylene glycol bis(2-aminoethyl) ether is an ether.

Not classified

Step 1, Synthesis of 1,6-dicyano-2,5-dioxohexane

Sodium hydride (88 g, 2.2 mol) and tetrahydrofuran were added to a 5L three-necked flask, and cooled to 0 C in an ice bath. A tetrahydrofuran solution of ethylene glycol (62.07 g, 1 mol) was added dropwise. Then the reaction was naturally raised to room temperature for 4h, then the ice bath was cooled down to 0C and a tetrahydrofuran solution of bromoacetonitrile (239.9g, 2.0 mol) was added dropwise to the reaction solution, which was naturally raised to room temperature after dropping, and the reaction was continued for 18h (overnight), and the reaction was stopped when mono-substituted impurities were monitored to be almost consumed by TLC. The reaction solution was cooled down and quenched with methanol, and a small amount of silica gel and diatomaceous earth was spread in a Brinell's funnel to filter the reaction solution, which was concentrated to obtain 113.5 g of 111,6-dicyano-2,5-dioxahexane in 81% yield.

Step 2, Synthesis of 1,8-diamino-3,6-dioxaoctane

1,6-dicyano-2,5-dioxohexane (100 g, 0.71 mol), 1 L of methanol, and Pd/C (25 g, 25%) were placed in a 2 L three-neck flask. Then hydrogen was passed into the reaction solution until the end of the reaction, and then the hydrogen was stopped. After filtration and concentration, crude 1,8-diamino-3,6-dioxaoctane was obtained, and 79.3 g of pure 1,8-diamino-3,6-dioxaoctane was obtained after distillation under reduced pressure in 75% yield.