(PEO)3-monoamine is a poly(ethylene oxide) (PEO) blocking reagent that prevents nonspecific adsorption of analytes in applications using covalent protein coupling such as ELISA. It reduces the adsorption of IgG when coated on carboxylic-terminated surfaces.
(PEO)3-Mono-amine can be used as a novel improved cutting fluid.
NH₂-PEG₃-OH (CAS 6338-55-2) is a high-purity, discrete, hetero-bifunctional PEG linker. Its synonyms include Amino-PEG3, Amine-PEG3-OH, (PEO)3-MONO-AMINE, Amino-PEG3-alcohol and 2-[2-(2-aminoethoxy)ethoxy]ethanol, amongst others. The NH₂-PEG₃-OH molecule consists of three parts: an amino group, a short chain comprising three PEG units, and a hydroxyl group. It can be used for peptide modification, the synthesis of small-molecule targeted drugs, ADCs and PROTACs. The amino group can react with carboxylic acids, activated NHS esters, and carbonyl groups (ketones, aldehydes); the hydroxyl group can be further converted into other functional groups. The PEG chains help to improve the solubility and stability of the drug.
The general procedure for the synthesis of 2-[2-(2-aminoethoxy)ethoxy]ethanol from 2-(2-(2-azidoethoxy)ethoxy)ethanol was as follows: 2-(2-(2-azidoethoxy)ethoxy)ethanol (0.7 g, 3.99 mmol) was dissolved in methanol (9 mL), followed by addition of a palladium/activated carbon catalyst (0.196 g) under stirring conditions . The reaction flask was subjected to three evacuation/hydrogen flush cycles to establish a hydrogen atmosphere. The progress of the reaction was monitored by thin layer chromatography (TLC), which showed the completion of the reaction after 8 hours. The reaction mixture was filtered through diatomaceous earth to remove the palladium/activated carbon catalyst. The filtrate was concentrated under reduced pressure to afford 2-[2-(2-aminoethoxy)ethoxy]ethanol as a colorless oil (0.6 g, quantitative yield).
[1] Helvetica Chimica Acta, 1991, vol. 74, # 8, p. 1697 - 1706
[2] Patent: US5144043, 1992, A
[3] Organic Letters, 2009, vol. 11, # 1, p. 193 - 196
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 2, p. 1151 - 1155
[5] Angewandte Chemie - International Edition, 2015, vol. 54, # 35, p. 10327 - 10330
![2-[2-(2-AZIDOETHOXY)ETHOXY]ETHANOL](/StructureFile/ChemBookStructure20/GIF/CB5648133.gif)
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