beige-pink crystalline powder
4-Amino-3,5-diiodobenzoic acid is a very useful substituted benzene compound for use as a building block in synthesis. The carboxylic acid and amine functionalities can be used to form linkages through nucleophile-electrophile coupling and the iodides may be used as functional sites for cross-coupling transformations. 4-Amino-3,5-diiodobenzoic acid has been specifically used in the synthesis of an adduct to introduce into Tecoflex polymers to impart radiopaqueness to the material.
Purify the iodo-acid by dissolving it in dilute NaOH and precipitating with dilute HCl. Alternatively, dissolve it in aqueous NH3 and acidify it with AcOH. Dry it in air. The solubility of the Na salt in H2O is 2.56% at 25o. [Klemme & Hunter J Org Chem 5 510 1940, Beilstein 14 H 439, 14 III 1161, 14 IV 1284.]
