3-Iodobenzoic acid is added as UV absorbing background electrolyte in separation of uncharged cyclodextrins and their derivatives by capillary electrophoresis.3-Iodobenzoic acid was used in solid phase synthesis of γ-turn mimetic library.
3-Iodobenzoic acid was used in solid phase synthesis of γ-turn mimetic library.
3-Iodobenzoic acid is used in solid phase synthesis of γ-turn mimetic library. It is used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuff.
ChEBI: 3-iodobenzoic acid is an iodobenzoic acid with a single iodo substituent placed at the 3-position.
3-Iodobenzoic acid is added as UV absorbing background electrolyte in separation of uncharged cyclodextrins and their derivatives by capillary electrophoresis.
The general procedure for the synthesis of 3-iodobenzoic acid from 3-carboxyphenylboronic acid was as follows: arylboronic acid 1 (0.5 mmol) and K2CO3 (1 mmol, 138.0 mg) were added to a 20 mL Schlenk tube fitted with a non-magnetic stir bar. The Schlenk tube was evacuated twice and backfilled with N2. MeCN (2 mL) and I2 (0.75 mmol, 191 mg) were added to the tube at room temperature. The Schlenk tube was sealed and placed in a preheated oil bath at 80 °C for 8-12 h under a stream of N2 gas. After completion of the reaction, the resulting solution was cooled to room temperature. H2O (10 mL) was added, and for the product 3-iodobenzoic acid, 1 M HCl was added to the aqueous solution until the pH reached 2 prior to extraction.The aqueous layer was extracted with EtOAc (3 x 5 mL). The organic phases were combined, dried with anhydrous Na2SO4, filtered and concentrated by rotary evaporation. Finally, the residue was purified by silica gel column chromatography to obtain the target product 3-iodobenzoic acid.
Crystallise the acid repeatedly from water and EtOH. Sublime it under vacuum at 100o. [Beilstein 9 IV 1033.]
[1] Synlett, 2014, vol. 25, # 7, p. 995 - 1000
[2] Chemistry - A European Journal, 2011, vol. 17, # 20, p. 5652 - 5660
