α-雌二醇
α-雌二醇 性质
| 熔点 | 176-180 °C(lit.) |
|---|---|
| 沸点 | 355.44°C (rough estimate) |
| 比旋光度 | D20 +53 to +56° (c = 0.9 in dioxane) |
| 密度 | 1.0708 (rough estimate) |
| 折射率 | 1.4800 (estimate) |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | 乙醇：50 mg/mL，澄清，无色 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 10.27±0.60(Predicted) |
| 颜色 | 白色略带黄色 |
| 生物来源 | synthetic (organic) |
| 水溶解性 | 3.9mg/L(25 ºC) |
| Merck | 14,3704 |
| InChI | 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1 |
| InChIKey | VOXZDWNPVJITMN-SFFUCWETSA-N |
| SMILES | [H][C@]12CC[C@]3(C)[C@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(O)ccc24 |
| CAS 数据库 | 57-91-0(CAS DataBase Reference) |
| NIST化学物质信息 | Estra-1,3,5(10)-triene-3,17alpha-diol(57-91-0) |
| EPA化学物质信息 | Estra-1,3,5(10)-triene-3,17-diol, (17.alpha.)- (57-91-0) |
α-雌二醇 用途与合成方法
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Human Endogenous Metabolite
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Alpha-Estradiol (17 alpha-Estradiol) is a 5α-reductase inhibitor, and inhibits testosterone metabolism catalyzed by 5 alpha-reductase. Alpha-Estradiol (17 Alpha-estradiol, 10 μM) attenuates LPS-induced inflammatory markers in both C57BL/6J male and female mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes and differentiated 3T3-L1 adipocytes in an ERα-dependent manner, and such effects are through decreased NFκB-p65 and increased ERα protein expression.
Alpha-Estradiol (17-alpha-estradiol, 0.01, 0.1, 1 μg) significantly reduces the percentage of central avascular/total retina area of the mouse pups. Alpha-Estradiol (1 μg) markedly decreasesmalondialdehyde (MDA) levels on postnatal days (PND) 9, 13, and 17 in retinas of hyperoxia-exposed pups. Alpha-Estradiol (1 μg) also decreases the number of NADPH-oxidase-positive cells, NADPH oxidase concentration and activity in retinas of the pups. In the 1.0-μg Alpha-Estradiol-treated pups, VEGF retinal concentrations are high on PND 9 but lower on PND 14 and 17. The best effect in retinas of 1.0-μg Alpha-Estradiol-treated pups is partly reversed by ICI182780 on PND 14 and 17.
Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17α-stradiol and its selective receptor, ER-X, are not part of a cl assical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain.17-Estradiol may have enormous implications for hormone replac ement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer disease and ischemic stroke.
安全信息
| 危险品标志 | T,Xn |
|---|---|
| 危险类别码 | 45-48-40 |
| 安全说明 | 53-45-24/25-22 |
| 危险品运输编号 | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS号 | KG3750000 |
| F | 8-10 |
| 海关编码 | 29372390 |
| 存储类别 | 6.1C - 可燃，急性毒性 类别3 毒性化合物或者引起慢性影响的化合物 |
| 危险性类别 | 危害水生环境-长期危害 类别1 致癌性 类别2 影响哺乳 生殖细胞致突变性 类别2 生殖毒性 类别1A |
α-雌二醇 化学药品说明书
α-雌二醇 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-B0141AR | α-雌二醇 | 57-91-0 | 5 mg | 233 |
| 2026-09-15 | HY-B0141AR | α-雌二醇 | 57-91-0 | 10 mg | 350 |
