α-雌二醇

生物活性靶点体外研究体内研究 α-雌二醇试剂级价格

α-雌二醇

CAS号:57-91-0
英文名:Estradiol
中文名:α-雌二醇
CBNumber:CB7289534
分子式:C18H24O2
分子量:272.39
MOL File:57-91-0.mol

α-雌二醇化学性质

熔点 :176-180 °C(lit.)
沸点 :355.44°C (rough estimate)
比旋光度 :D20 +53 to +56° (c = 0.9 in dioxane)
密度 :1.0708 (rough estimate)
折射率 :1.4800 (estimate)
储存条件 :Sealed in dry,Room Temperature
溶解度 :ethanol: 50 mg/mL, clear, colorless
形态 :powder
酸度系数(pKa) :10.27±0.60(Predicted)
颜色 :white with slight yellow
水溶解性 :3.9mg/L(25 ºC)
Merck :14,3704
CAS 数据库 :57-91-0(CAS DataBase Reference)
NIST化学物质信息 :Estra-1,3,5(10)-triene-3,17alpha-diol(57-91-0)
EPA化学物质信息 :Estra-1,3,5(10)-triene-3,17-diol, (17.alpha.)- (57-91-0)

安全信息

危险品标志 :T,Xn
危险类别码 :45-48-40
安全说明 :53-45-24/25-22
危险品运输编号 :UN 2811 6.1/PG 2
WGK Germany :3
RTECS号 :KG3750000
F :8-10
海关编码 :29372390

α-雌二醇化学药品说明书

雌二醇|药典2005版
雌二醇缓释贴片—雌二醇的测定—高效液相色谱法|药物分析方法信息

α-雌二醇性质、用途与生产工艺

生物活性 Alpha-Estradiol 是一种雌性激素，是 5α-reductase 抑制剂，有潜力用于雄原性脱发的研究。
靶点

Human Endogenous Metabolite
体外研究

Alpha-Estradiol (17 alpha-Estradiol) is a 5α-reductase inhibitor, and inhibits testosterone metabolism catalyzed by 5 alpha-reductase. Alpha-Estradiol (17 Alpha-estradiol, 10 μM) attenuates LPS-induced inflammatory markers in both C57BL/6J male and female mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes and differentiated 3T3-L1 adipocytes in an ERα-dependent manner, and such effects are through decreased NFκB-p65 and increased ERα protein expression.
体内研究

Alpha-Estradiol (17-alpha-estradiol, 0.01, 0.1, 1 μg) significantly reduces the percentage of central avascular/total retina area of the mouse pups. Alpha-Estradiol (1 μg) markedly decreasesmalondialdehyde (MDA) levels on postnatal days (PND) 9, 13, and 17 in retinas of hyperoxia-exposed pups. Alpha-Estradiol (1 μg) also decreases the number of NADPH-oxidase-positive cells, NADPH oxidase concentration and activity in retinas of the pups. In the 1.0-μg Alpha-Estradiol-treated pups, VEGF retinal concentrations are high on PND 9 but lower on PND 14 and 17. The best effect in retinas of 1.0-μg Alpha-Estradiol-treated pups is partly reversed by ICI182780 on PND 14 and 17.
用途治疗功能性子宫出血、原发性闭经、绝经期综合症等。
用途
Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17α-stradiol and its selective receptor, ER-X, are not part of a cl assical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain.17-Estradiol may have enormous implications for hormone replac ement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer disease and ischemic stroke.