生物活性 靶点 体外研究 体内研究 17α-雌二醇 试剂级价格
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17α-雌二醇

17α-雌二醇,57-91-0,结构式
17α-雌二醇
  • CAS号:57-91-0
  • 英文名:Estradiol
  • 中文名:17α-雌二醇
  • CBNumber:CB00129057
  • 分子式:C18H24O2
  • 分子量:272.39
  • MOL File:57-91-0.mol
17α-雌二醇化学性质
安全信息
  • 危险品标志 :T,Xn
  • 危险类别码 :45-48-40
  • 安全说明 :53-45-24/25-22
  • 危险品运输编号 :UN 2811 6.1/PG 2
  • WGK Germany :3
  • RTECS号 :KG3750000
  • F :8-10
  • 海关编码 :29372390

α-雌二醇 化学药品说明书


雌二醇|药典2005版
雌二醇缓释贴片—雌二醇的测定—高效液相色谱法|药物分析方法信息

17α-雌二醇性质、用途与生产工艺

  • 生物活性 Alpha-Estradiol 是一种雌性激素,是 5α-reductase 抑制剂,有潜力用于雄原性脱发的研究。
  • 靶点

    Human Endogenous Metabolite

  • 体外研究

    Alpha-Estradiol (17 alpha-Estradiol) is a 5α-reductase inhibitor, and inhibits testosterone metabolism catalyzed by 5 alpha-reductase. Alpha-Estradiol (17 Alpha-estradiol, 10 μM) attenuates LPS-induced inflammatory markers in both C57BL/6J male and female mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes and differentiated 3T3-L1 adipocytes in an ERα-dependent manner, and such effects are through decreased NFκB-p65 and increased ERα protein expression.

  • 体内研究

    Alpha-Estradiol (17-alpha-estradiol, 0.01, 0.1, 1 μg) significantly reduces the percentage of central avascular/total retina area of the mouse pups. Alpha-Estradiol (1 μg) markedly decreasesmalondialdehyde (MDA) levels on postnatal days (PND) 9, 13, and 17 in retinas of hyperoxia-exposed pups. Alpha-Estradiol (1 μg) also decreases the number of NADPH-oxidase-positive cells, NADPH oxidase concentration and activity in retinas of the pups. In the 1.0-μg Alpha-Estradiol-treated pups, VEGF retinal concentrations are high on PND 9 but lower on PND 14 and 17. The best effect in retinas of 1.0-μg Alpha-Estradiol-treated pups is partly reversed by ICI182780 on PND 14 and 17.

  • 用途  治疗功能性子宫出血、原发性闭经、绝经期综合症等。
  • 用途 

    Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17α-stradiol and its selective receptor, ER-X, are not part of a cl assical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain.17-Estradiol may have enormous implications for hormone replac ement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer disease and ischemic stroke.

17α-雌二醇上下游产品信息
上游原料
下游产品
17α-雌二醇 试剂级价格
  • 更新日期:2024/08/19
  • 产品编号:HY-B0141A
  • 产品名称:α-雌二醇 Alpha-Estradiol
  • CAS编号:57-91-0
  • 包装:100mg
  • 价格:750元
  • 更新日期:2024/08/19
  • 产品编号:HY-B0141A
  • 产品名称:α-雌二醇 Alpha-Estradiol
  • CAS编号:57-91-0
  • 包装:10mM * 1mLin DMSO
  • 价格:825元
17α-雌二醇生产厂家
  • 公司名称:台州市科瑞生物技术有限公司
  • 联系电话:+86-0576-88813233 +86-13396860566
  • 电子邮件:sales@pharm-intermediates.com
  • 国家:中国
  • 产品数:1990
  • 优势度:58
  • 公司名称:武汉东康源科技有限公司
  • 联系电话:027-81302411 15377658509
  • 电子邮件:zs@dkybpc.com
  • 国家:中国
  • 产品数:2190
  • 优势度:58
  • 公司名称:北京百灵威科技有限公司
  • 联系电话:010-82848833 400-666-7788
  • 电子邮件:jkinfo@jkchemical.com
  • 国家:中国
  • 产品数:94657
  • 优势度:76
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