基本属性 生物活性体外研究体内研究 用途与合成方法 供应商 相关产品
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KW-2478

基本属性 生物活性体外研究体内研究 用途与合成方法 供应商 相关产品
KW-2478
KW-2478 性质
  • 密度 1.209
KW-2478 用途与合成方法
  • 生物活性KW-2478是一种非Ansamycin的HSP90抑制剂,IC50为3.8 nM。Phase 1。
  • 体外研究KW-2478 inhibits the binding of bRD to Hsp90α with IC50 of 3.8 nM. KW-2478 degradates the Hsp90 client proteins, including FGFR3 and IGF-1Rβand c-Raf-1. KW-2478 reduces the level of phosphorylated Erk1/2. KW-2478 induces apoptosis by cleavage of PARP, a substrate of caspase-3 In U266 cells,. KW-2478 has Time dependency of antiproliferative activity, consecutive drug exposure for at least 12 hours is necessary to to exert potent antitumor activity. KW-2478 downregulates the translocation products of IgH locus. KW-2478 inhibits the transcription of c-Maf and cyclin D1 genes by mainly suppressing the function of Cdk9. KW-2478 has potent and broad growth inhibitory activities against various cell lines, KW-2478 inhibites cancer cell growth in all cell lines, with EC50 of 101-252 nM, 81.4-91.4 nM and 120-622 nM for B-cell lymphoma, mantle cell lymphoma and multiple myeloma, respectively. KW-2478 also shows potent growth inhibitory activity in primary CLL and NHL cells with EC50 of 40-170 nM and 200-400 nM, respectively. .
  • 体内研究KW-2478 suppresses tumor growth and induces the degradation of client proteins in tumors in NCI-H929 s.c. inoculated model at doses of 100 mg/kg or more. KW-2478 reduces both serum M protein and MM tumor burden in the bone marrow in OPM-2/GFP i.v. inoculated mouse model at doses of 100 mg/kg.
KW-2478供应商更多
  • 公司名称:上海波以尔化工有限公司
  • 联系电话:86-15221043597
  • 产品介绍: 英文名称:KW-2478
    CAS:819812-04-9
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  • 公司名称:上海景颜化工科技有限公司
  • 联系电话:13817811078,021-50426030
  • 产品介绍: 英文名称:KW-2478
    纯度:98%
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  • 公司名称:武汉永璨生物科技有限公司
  • 联系电话:0086-27-5925 3327; QQ:40199614
  • 产品介绍: 英文名称:KW-2478
    CAS:819812-04-9
    纯度:98.0% 包装信息:1400RMB/50.0mg 备注:only used for research
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  • 公司名称:济南精合医药科技有限公司
  • 联系电话:+86 (531) 88811783;
  • 产品介绍: 英文名称:KW-2478
    CAS:819812-04-9
    纯度:99% 包装信息:5Mg, 10Mg, 20Mg, 50Mg
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  • 公司名称:BOC Sciences
  • 联系电话:
  • 产品介绍: 英文名称:KW-2478
    CAS:819812-04-9
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"KW-2478"相关产品信息