Iriflophene

Iriflophenone, isolated from Aquilaria sinensis, stimulates MCF-7 and T-47D human breast cancer cells proliferation[1][2].

Preparation by reaction of p-hydroxybenzonitrile with phloroglucinol, (15%) (Hoesch reaction).

Estrogen receptor | Progestogen receptor

[1] Monthakantirat O, et al. Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. J Nat Prod. 2005;68(3):361-364. DOI:10.1021/np040175c
[2] Kumar V, et al. Detection of intermediates through high-resolution mass spectrometry for constructing biosynthetic pathways for major chemical constituents in a medicinally important herb, Swertia chirayita. Nat Prod Res. 2015;29(15):1449-1455. DOI:10.1080/14786419.2015.1004175