三氯卡班
三氯卡班 性质
| 熔点 | 254-256 °C (lit.) |
|---|---|
| 沸点 | 344.2±42.0 °C(Predicted) |
| 密度 | 1.5732 (rough estimate) |
| 蒸气压 | <0.1 mm Hg ( 25 °C) |
| 折射率 | 1.6300 (estimate) |
| 闪点 | 150 °C |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | 可溶于甲醇： |
| 酸度系数(pKa) | 12.77±0.70(Predicted) |
| 形态 | 固体 |
| 颜色 | 片状 |
| 水溶解性 | <0.1 g/100 mL at 26 ºC |
| Merck | 14,9654 |
| 稳定性 | 稳定的。易燃。与强氧化剂强碱不相容。 |
| InChIKey | ICUTUKXCWQYESQ-UHFFFAOYSA-N |
| LogP | 3.633 at 25℃ |
| CAS 数据库 | 101-20-2(CAS DataBase Reference) |
| NIST化学物质信息 | 3,4,4'-Trichloro carbanilide(101-20-2) |
| EPA化学物质信息 | Triclocarban (101-20-2) |
三氯卡班 用途与合成方法
Bacterial
Triclocarban (300 nM) potentiates the cytotoxicity of 300 µM H 2 O 2 in rat thymocytes. Triclocarban (300 nM) does not increase the population of death cells, it facilitates the process of cell death induced by H 2 O 2 , resulting in further increase in the population of dead cells. Triclocarban exertes estrogenic activities by inducing luciferase activities in an ER reporter gene assay, promoting the proliferation of the MCF-7 cells, up-regulating the expression of pS2 and down-regulating ERα expression at both the mRNA and protein levels in the MCF-7 cells.
Triclocarban is absorbed significantly from soap used during showering in human subjects and that its C max in their whole blood ranges from 23 nM to 530 nM. Gestational triclocarban exposure does not affect the ability of dams to carry offspring to term but triclocarban exposure during lactation has adverse consequences on the survival of offspring.
安全信息
| 危险品标志 | N |
|---|---|
| 危险类别码 | 50/53 |
| 安全说明 | 60-61 |
| 危险品运输编号 | UN 3077 9/PG 3 |
| WGK Germany | 2 |
| RTECS号 | FE1250000 |
| 危险等级 | 9 |
| 包装类别 | III |
| 海关编码 | 38220090 |
| 毒害物质数据 | 101-20-2(Hazardous Substances Data) |
| 毒性 | LD50 ipr-mus: 2100 mg/kg LPPTAK 27,306,79 |
三氯卡班 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-11 | XW01012022 | 三氯卡班 | 101-20-2 | 100G | 64 |
| 2024-11-11 | XW01012021 | 三氯卡班 | 101-20-2 | 25G | 37 |
