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Tiamulin

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Tiamulin Basic information
Tiamulin Chemical Properties
  • Melting point:147.5°C
  • Boiling point:563.0±50.0 °C(Predicted)
  • Density 1.0160 (rough estimate)
  • refractive index 1.6550 (estimate)
  • form neat
  • pka14.65±0.70(Predicted)
  • CAS DataBase Reference55297-95-5(CAS DataBase Reference)
  • EPA Substance Registry SystemTiamulin (55297-95-5)
Safety Information
Tiamulin Usage And Synthesis
  • UsesTiamulin is a semi–synthetic analogue of pleuromutilin in which the hydroxyacetyl side chain is replaced with a larger diethylaminoethylthioacetyl moiety, providing greater hydrophobicity and an ionisable group for salt formation and greater water solubility. Tiamulin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action. Like pleuromutilin, it inhibits protein synthesis by binding to domain V of 23S rRNA.
  • DefinitionChEBI: A carbotricyclic compound that is pleuromutilin in which the hydroxyacetate group is replaced by a 2-{[2-(diethylamino)ethyl]sulfanyl}acetate group. An antibacterial drug, tiamulin is used in veterinary medicine (generally as its hydrogen fumarate salt) fo the treatment of swine dysentery caused by Serpulina hyodysenteriae.
  • Safety ProfilePoison by intramuscular and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of SOx and NOx. See also MERCAPTANS.
  • Veterinary Drugs and TreatmentsTiamulin is approved for use in swine to treat pneumonia caused by susceptible strains of Haemophilus pleuropneumoniae and swine dysentery caused by Treponema hyodysenteriae. As a feed additive, it is used to cause increased weight gain in swine.
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