Synephrine (1 mg/kg; oral gavage; for 8 days; PVL and BDL rats) significantly ameliorates the hyperdynamic state in both PVL and BDL rats. The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index are significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance are enhanced by treatment of Synephrine[2].
| Animal Model: | Portal vein ligation (PVL) or bile duct ligation (BDL) rats[2]. |
| Dosage: | 1 mg/kg per 12 hours
|
| Administration: | Oral gavage; for 8 days |
| Result: | The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index were significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance were enhanced. |
