ChemicalBook Product Catalog Biochemical Engineering Biochemical Reagents Biological Dyes Thioflavin T

Thioflavin T

Product NameThioflavin T
CAS2390-54-7
MFC17H19ClN2S
MW318.86
EINECS219-228-9
MOL File2390-54-7.mol

Chemical Properties

Melting point	211-212 °C (decomp)
Density	1.301g/cm3 at 20℃
vapor pressure	0Pa at 25℃
storage temp.	Store below +30°C.
solubility	methanol: soluble1mg/mL
Colour Index	49005
form	Powder
color	Yellow to ochre-yellow
BRN	3922452
InChI	InChI=1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1
InChIKey	JADVWWSKYZXRGX-UHFFFAOYSA-M
SMILES	C1(=[N+](C)C2C=CC(C)=CC=2S1)C1C=CC(N(C)C)=CC=1.[Cl-]
LogP	3.02 at 25℃ and pH7.98
CAS DataBase Reference	2390-54-7(CAS DataBase Reference)
EPA Substance Registry System	Benzothiazolium, 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-, chloride (2390-54-7)

Safety Information

Safety Statements	24/25
RIDADR	2811
WGK Germany	3
TSCA	Yes
HazardClass	6.1(b)
PackingGroup	III
HS Code	32041300

MSDS

Provider	Language
Basic Yellow 1	English
SigmaAldrich	English
ACROS	English

Usage And Synthesis

Chemical Properties

yellow to ochre-yellow powder

Uses

A dye used to visualize beta-amyloid plaques, like those associated with Alzheimer's Disease

Uses

Textile dyeing, fluorescent sign paints, in combination with green or blue pigments to produce brilliant greens, phosphotungstic pigments.

Definition

ChEBI: Thioflavine T is an organic chloride salt having 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium as the counterion. It is widely used to visualise and quantify the presence of amyloids, both in vitro and in vivo. It has a role as a fluorochrome, a histological dye and a geroprotector. It contains a thioflavin T cation.

Preparation

4-(6-Methyl-2,3-dihydrobenzo[d]thiazol-2-yl)benzenamine?with methanol and hydrochloric acid or sulfuric acid, at 160 ~ 170 ℃ methylation under pressure.

General Description

Thioflavin T is a benzothiazole dye that increases in fluorescence upon binding to amyloid. Thioflavin T has been used in histology and for protein characterization.

Biochem/physiol Actions

Cell permeable: yes

storage

Store at -20°C

Properties and Applications

colourful green light yellow. Soluble in cold water, soluble in hot water for yellow, easily soluble in ethanol and yellow, with green fluorescent. The strong sulfuric acid to colorless, a green fluorescent, diluted into light yellow.