Basic information Safety Related Supplier
ChemicalBook >  Product Catalog >  API >  Antibiotics >  Other antibiotic Drugs >  CYTOCHALASIN B

CYTOCHALASIN B

Basic information Safety Related Supplier
CYTOCHALASIN B Basic information
CYTOCHALASIN B Chemical Properties
  • Melting point:218-223 °C
  • Boiling point:577.96°C (rough estimate)
  • Density 1.1490 (rough estimate)
  • refractive index 1.6290 (estimate)
  • Flash point:85℃
  • storage temp. -20°C
  • solubility ethanol: 20 mg/mL
  • form powder
  • pka13.60±0.70(Predicted)
  • color white
  • Merck 13,2819
  • BRN 1096207
  • InChIKeyUXVDBQLLXVKPRS-UZBFCAAUSA-N
  • EPA Substance Registry SystemCytochalasin B (14930-96-2)
Safety Information
MSDS
CYTOCHALASIN B Usage And Synthesis
  • Chemical Propertieswhite to off-white powder
  • UsesCytochalasin B is one of the most extensively studied members of a family of potent mycotoxins produced by several species of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, giving rise to pronounced morphogenic activity in animals and plants. Like most cytochalsins, cytochalasin B exhibits potent inhibition of actin filament function leading to cell death by apoptosis, and displays a broad range of resultant cellular actions. Despite the common mode of action, there is evidence that individual members of this class display diverse selectivity. However, lack of comparative co-metabolite analysis has restricted a more complete understanding of their individual selectivity.
  • UsesA cell-permeable fungal toxin used in actin polymerization studies and cytological
  • UsesAs tools in cytological research and in characterization of polymerization properties of actin, q.v.
  • DefinitionChEBI: An organic heterotricyclic compound, that is a mycotoxin which is cell permeable an an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments.
  • Purification MethodsPurify it by MeOH extraction, reverse phase C18 silica gel batch extraction by selective elution with 1:1 v/v hexane/tetrahydrofuran, crystallisation, subjected to TLC and recrystallisation [Lipski et al. Anal Biochem 161 332 1987]. It is soluble in EtOH (3.6%), Me2CO (1%), Me2SO (37%) and Me2NCHO (49%) at 24o, and can be crystallised from the first two solvents. It interferes with cellular movement [Korm Physiol Reviews 62 672 1982].
CYTOCHALASIN B(14930-96-2)Related Product Information
CYTOCHALASIN BSupplierMore
  • Company Name:Dalian Meilun Biotech Co., Ltd. Gold
  • Tel:041162910999 0411-62910999-
  • Email:sales@meilune.com;sales@meilune.com
  •  
  • Company Name:Beijing Solarbio Science & Tecnology Co., Ltd. Gold
  • Tel:010-50973129
  • Email:405465416@qq.com
  •  
  • Company Name:MedBio?Pharmaceutical Technology Inc Gold
  • Tel:18916172912 021-69568360-
  • Email:order@med-bio.cn
  •  
  • Company Name:J & K SCIENTIFIC LTD.
  • Tel:400-666-7788 010-82848833-
  • Email:jkinfo@jkchemical.com;market6@jkchemical.com
  •  
  • Company Name:Meryer (Shanghai) Chemical Technology Co., Ltd.
  • Tel:400-660-8290 21-61259100-
  • Email:sh@meryer.com
  •